TY - JOUR
T1 - Association of long-term exposure to ambient air pollutants with blood lipids in Chinese adults
T2 - The China Multi-Ethnic Cohort study
AU - Wang, Lei
AU - Chen, Gongbo
AU - Pan, Yongyue
AU - Xia, Jingjie
AU - Chen, Liling
AU - Zhang, Xiaoqing
AU - Silang, Yangzong
AU - Chen, Jiayi
AU - Xu, Huan
AU - Zeng, Chunmei
AU - Wei, Jing
AU - Li, Shanshan
AU - Guo, Yuming
AU - Yang, Shujuan
AU - Hong, Feng
AU - Zhao, Xing
AU - on behalf of the China Multi-Ethnic Cohort (CMEC) collaborative group
N1 - Funding Information:
This work was supported by the National Key Research and Development Program of China (Grant No. 2017YFC0907303 ) and the National Natural Science Foundation of China (Grant No. 81773548 and 81973151 ).
Publisher Copyright:
© 2021 Elsevier Inc.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/6
Y1 - 2021/6
N2 - Background: Dyslipidemia is a crucial risk factor for cardiovascular diseases. Previous studies have suggested that air pollution is associated with blood lipids. However, little evidence exists in low- and middle-income regions. We aimed to investigate the association between air pollution and blood lipids in southwestern China. Methods: We included 67,305 participants aged 30–79 years from the baseline data of the China Multi-Ethnic Cohort (CMEC) study. Three-year average concentrations of particles with diameters ≤1 μm (PM1), particles with diameters ≤ 2.5 μm (PM2.5), particles with diameters ≤ 10 μm (PM10), nitrogen dioxide (NO2), and ozone (O3) were estimated using satellite-based spatiotemporal models. Individual serum lipids, including cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C), were measured. Linear, logistic, and quantile regression models were used to evaluate the association between ambient air pollution and blood lipids. Results: All five air pollutants in our study were associated with lipid levels. Increased air pollution exposure was associated with a high risk of dyslipidemia. Each 10 μg/m3 increase in PM2.5 was associated with 0.92% (95% confidence interval (CI): 0.64%, 1.20%), 2.23% (95% CI: 1.44%, 3.02%), and 3.04% (95% CI: 2.61%, 3.47%) increases in TC, TG, and LDL-C levels, respectively, and a 2.03% (95% CI: 1.69%, 2.37%) decrease in HDL-C levels, and high risks of dyslipidemia (OR = 1.14, 95% CI: 1.10, 1.18). Stronger associations of air pollution with blood lipids were found in participants with high lipid levels than in those with low lipid levels. Conclusion: Long-term exposure to air pollutants was associated with blood lipid levels and the risk of dyslipidemia. People with high lipid levels were more susceptible to air pollution. Therefore, air pollution prevention and control may help reduce the incidence of dyslipidemia and the burden of CVDs.
AB - Background: Dyslipidemia is a crucial risk factor for cardiovascular diseases. Previous studies have suggested that air pollution is associated with blood lipids. However, little evidence exists in low- and middle-income regions. We aimed to investigate the association between air pollution and blood lipids in southwestern China. Methods: We included 67,305 participants aged 30–79 years from the baseline data of the China Multi-Ethnic Cohort (CMEC) study. Three-year average concentrations of particles with diameters ≤1 μm (PM1), particles with diameters ≤ 2.5 μm (PM2.5), particles with diameters ≤ 10 μm (PM10), nitrogen dioxide (NO2), and ozone (O3) were estimated using satellite-based spatiotemporal models. Individual serum lipids, including cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C), were measured. Linear, logistic, and quantile regression models were used to evaluate the association between ambient air pollution and blood lipids. Results: All five air pollutants in our study were associated with lipid levels. Increased air pollution exposure was associated with a high risk of dyslipidemia. Each 10 μg/m3 increase in PM2.5 was associated with 0.92% (95% confidence interval (CI): 0.64%, 1.20%), 2.23% (95% CI: 1.44%, 3.02%), and 3.04% (95% CI: 2.61%, 3.47%) increases in TC, TG, and LDL-C levels, respectively, and a 2.03% (95% CI: 1.69%, 2.37%) decrease in HDL-C levels, and high risks of dyslipidemia (OR = 1.14, 95% CI: 1.10, 1.18). Stronger associations of air pollution with blood lipids were found in participants with high lipid levels than in those with low lipid levels. Conclusion: Long-term exposure to air pollutants was associated with blood lipid levels and the risk of dyslipidemia. People with high lipid levels were more susceptible to air pollution. Therefore, air pollution prevention and control may help reduce the incidence of dyslipidemia and the burden of CVDs.
KW - Ambient air pollution
KW - Blood lipids
KW - Dyslipidemia
KW - Long-term
UR - http://www.scopus.com/inward/record.url?scp=85105896720&partnerID=8YFLogxK
U2 - 10.1016/j.envres.2021.111174
DO - 10.1016/j.envres.2021.111174
M3 - Article
C2 - 33894235
AN - SCOPUS:85105896720
VL - 197
JO - Environmental Research
JF - Environmental Research
SN - 0013-9351
M1 - 111174
ER -
