Association of GRIN2B gene polymorphism and Obsessive Compulsive disorder and symptom dimensions: A pilot study

Fabiana Barzotti Kohlrausch; Isabele Gomes Giori; Fernanda Brito Melo-Felippe; Tamiris Vieira-Fonseca; Luis Guillermo Coca Velarde; Juliana Braga de Salles Andrade; Leonardo Franklin Fontenelle

doi:10.1016/j.psychres.2016.06.027

Association of GRIN2B gene polymorphism and Obsessive Compulsive disorder and symptom dimensions: A pilot study

Fabiana Barzotti Kohlrausch
, Isabele Gomes Giori
, Fernanda Brito Melo-Felippe
, Tamiris Vieira-Fonseca
, Luis Guillermo Coca Velarde
, Juliana Braga de Salles Andrade
, Leonardo Franklin Fontenelle

Psychology

Research output: Contribution to journal › Article › Research › peer-review

30 Citations (Scopus)

Abstract

The etiology of OCD is largely unknown, but neuroimaging and pharmacological studies suggest that glutamatergic system plays a significant role on OCD development. We genotyped one polymorphism at GRIN2B (rs1019385) by real time Polymerase Chain Reaction in a sample of Brazilian Obsessive-Compulsive patients and healthy controls, and evaluated its influence on OCD. We found the T-allele and TT genotype to be significantly associated with OCD and ordering dimension. The T-allele was also significantly associated with checking. These preliminary results demonstrated that the GRIN2B gene may confer to some extent the susceptibility to OCD and its symptoms.

Original language	English
Pages (from-to)	152-155
Number of pages	4
Journal	Psychiatry Research
Volume	243
DOIs	https://doi.org/10.1016/j.psychres.2016.06.027
Publication status	Published - 30 Sept 2016

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Brazil
Genetics
Symptom dimensions

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10.1016/j.psychres.2016.06.027

Cite this

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title = "Association of GRIN2B gene polymorphism and Obsessive Compulsive disorder and symptom dimensions: A pilot study",

abstract = "The etiology of OCD is largely unknown, but neuroimaging and pharmacological studies suggest that glutamatergic system plays a significant role on OCD development. We genotyped one polymorphism at GRIN2B (rs1019385) by real time Polymerase Chain Reaction in a sample of Brazilian Obsessive-Compulsive patients and healthy controls, and evaluated its influence on OCD. We found the T-allele and TT genotype to be significantly associated with OCD and ordering dimension. The T-allele was also significantly associated with checking. These preliminary results demonstrated that the GRIN2B gene may confer to some extent the susceptibility to OCD and its symptoms.",

keywords = "Brazil, Genetics, Symptom dimensions",

author = "Kohlrausch, \{Fabiana Barzotti\} and Giori, \{Isabele Gomes\} and Melo-Felippe, \{Fernanda Brito\} and Tamiris Vieira-Fonseca and Velarde, \{Luis Guillermo Coca\} and \{de Salles Andrade\}, \{Juliana Braga\} and Fontenelle, \{Leonardo Franklin\}",

year = "2016",

month = sep,

day = "30",

doi = "10.1016/j.psychres.2016.06.027",

language = "English",

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journal = "Psychiatry Research",

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TY - JOUR

T1 - Association of GRIN2B gene polymorphism and Obsessive Compulsive disorder and symptom dimensions

T2 - A pilot study

AU - Kohlrausch, Fabiana Barzotti

AU - Giori, Isabele Gomes

AU - Melo-Felippe, Fernanda Brito

AU - Vieira-Fonseca, Tamiris

AU - Velarde, Luis Guillermo Coca

AU - de Salles Andrade, Juliana Braga

AU - Fontenelle, Leonardo Franklin

PY - 2016/9/30

Y1 - 2016/9/30

N2 - The etiology of OCD is largely unknown, but neuroimaging and pharmacological studies suggest that glutamatergic system plays a significant role on OCD development. We genotyped one polymorphism at GRIN2B (rs1019385) by real time Polymerase Chain Reaction in a sample of Brazilian Obsessive-Compulsive patients and healthy controls, and evaluated its influence on OCD. We found the T-allele and TT genotype to be significantly associated with OCD and ordering dimension. The T-allele was also significantly associated with checking. These preliminary results demonstrated that the GRIN2B gene may confer to some extent the susceptibility to OCD and its symptoms.

AB - The etiology of OCD is largely unknown, but neuroimaging and pharmacological studies suggest that glutamatergic system plays a significant role on OCD development. We genotyped one polymorphism at GRIN2B (rs1019385) by real time Polymerase Chain Reaction in a sample of Brazilian Obsessive-Compulsive patients and healthy controls, and evaluated its influence on OCD. We found the T-allele and TT genotype to be significantly associated with OCD and ordering dimension. The T-allele was also significantly associated with checking. These preliminary results demonstrated that the GRIN2B gene may confer to some extent the susceptibility to OCD and its symptoms.

KW - Brazil

KW - Genetics

KW - Symptom dimensions

UR - https://www.scopus.com/pages/publications/84978200145

U2 - 10.1016/j.psychres.2016.06.027

DO - 10.1016/j.psychres.2016.06.027

M3 - Article

AN - SCOPUS:84978200145

SN - 0165-1781

VL - 243

SP - 152

EP - 155

JO - Psychiatry Research

JF - Psychiatry Research

ER -

Association of GRIN2B gene polymorphism and Obsessive Compulsive disorder and symptom dimensions: A pilot study

Abstract

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Keywords

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