TY - JOUR
T1 - Association of GRIN2B gene polymorphism and Obsessive Compulsive disorder and symptom dimensions
T2 - A pilot study
AU - Kohlrausch, Fabiana Barzotti
AU - Giori, Isabele Gomes
AU - Melo-Felippe, Fernanda Brito
AU - Vieira-Fonseca, Tamiris
AU - Velarde, Luis Guillermo Coca
AU - de Salles Andrade, Juliana Braga
AU - Fontenelle, Leonardo Franklin
PY - 2016/9/30
Y1 - 2016/9/30
N2 - The etiology of OCD is largely unknown, but neuroimaging and pharmacological studies suggest that glutamatergic system plays a significant role on OCD development. We genotyped one polymorphism at GRIN2B (rs1019385) by real time Polymerase Chain Reaction in a sample of Brazilian Obsessive-Compulsive patients and healthy controls, and evaluated its influence on OCD. We found the T-allele and TT genotype to be significantly associated with OCD and ordering dimension. The T-allele was also significantly associated with checking. These preliminary results demonstrated that the GRIN2B gene may confer to some extent the susceptibility to OCD and its symptoms.
AB - The etiology of OCD is largely unknown, but neuroimaging and pharmacological studies suggest that glutamatergic system plays a significant role on OCD development. We genotyped one polymorphism at GRIN2B (rs1019385) by real time Polymerase Chain Reaction in a sample of Brazilian Obsessive-Compulsive patients and healthy controls, and evaluated its influence on OCD. We found the T-allele and TT genotype to be significantly associated with OCD and ordering dimension. The T-allele was also significantly associated with checking. These preliminary results demonstrated that the GRIN2B gene may confer to some extent the susceptibility to OCD and its symptoms.
KW - Brazil
KW - Genetics
KW - Symptom dimensions
UR - http://www.scopus.com/inward/record.url?scp=84978200145&partnerID=8YFLogxK
U2 - 10.1016/j.psychres.2016.06.027
DO - 10.1016/j.psychres.2016.06.027
M3 - Article
AN - SCOPUS:84978200145
SN - 0165-1781
VL - 243
SP - 152
EP - 155
JO - Psychiatry Research
JF - Psychiatry Research
ER -
