Association of contemporary sensitive troponin I levels at baseline and change at 1 year with long-term coronary events following myocardial infarction or unstable angina

Harvey D White, Andrew Maxwell Tonkin, John Simes, Ralph Stewart, Kristy Mann, Peter L Thompson, David Colquhoun, Malcolm J West, Paul J Nestel, David Sullivan, Anthony C Keech, David James Hunt, Stefan Blankenberg

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Abstract

Objectives This study sought to assess whether baseline and change in contemporary sensitive troponin I (TnI) levels predicts coronary heart disease (CHD) death and myocardial infarction (MI), and to determine the effects of pravastatin on TnI levels. Background The role of troponins in predicting long-term outcomes in patients with stable CHD is not clearly defined. Methods The LIPID (Long-Term Intervention With Pravastatin in Ischaemic Disease) study randomized patients with cholesterol levels of 155 to 271 mg/dl 3 to 36 months after MI or unstable angina to placebo or pravastatin 40 mg per day. TnI levels were measured at baseline and after 1 year in 7,863 patients. Median follow-up was 6 years. Change in TnI was defined as moving up or down 1 tertile or =50 change. Results Baseline TnI tertiles were
Original languageEnglish
Pages (from-to)345 - 354
Number of pages10
JournalJournal of the American College of Cardiology
Volume63
Issue number4
DOIs
Publication statusPublished - 2014

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