Association of chemotherapeutic drugs with dendrimer nanocarriers: an assessment of the merits of covalent conjugation compared to noncovalent encapsulation

Lisa Michelle Kaminskas, Victoria Mary McLeod, Christopher John Porter, Benjamin James Boyd

Research output: Contribution to journalArticleResearchpeer-review

104 Citations (Scopus)

Abstract

There is much current research into improving chemotherapy using approaches based on nanotechnology and polymer chemistry. In this review, the issues around approaches to improving chemotherapy using such constructs are briefly introduced, before focusing on an interesting class of globular polymers (dendrimers) as nanocarriers for chemotherapy drugs. The nature of association of the drug to the dendritic carrier is critical to the delivery of chemotherapeutics. So far, however, an examination of which of these two approaches is most ideally suited to the development of tumor delivery systems for chemotherapeutic drugs has been limited to a few isolated studies. Consequently, in this review we compare the known outcomes of the two broad drug association strategies to enable a rational conclusion to be drawn about the most likely successful strategies to employ in designing and developing dendrimer-based drug delivery systems.
Original languageEnglish
Pages (from-to)355 - 373
Number of pages19
JournalMolecular Pharmaceutics
Volume9
Issue number3
DOIs
Publication statusPublished - 2012

Cite this