Association of celiac disease genes with inflammatory bowel disease in Finnish and Swedish patients

A. S. Parmar; M. Lappalainen; P. Paavola-Sakki; L. Halme; M. Färkkilä; U. Turunen; K. Kontula; A. Aromaa; V. Salomaa; L. Peltonen; J. Halfvarson; L. Törkvist; M. D'Amato; P. Saavalainen; E. Einarsdottir

doi:10.1038/gene.2012.21

Association of celiac disease genes with inflammatory bowel disease in Finnish and Swedish patients

A. S. Parmar
, M. Lappalainen
, P. Paavola-Sakki
, L. Halme
, M. Färkkilä
, U. Turunen
, K. Kontula
, A. Aromaa
, V. Salomaa
, L. Peltonen
, J. Halfvarson
, L. Törkvist
, M. D'Amato
, P. Saavalainen
, E. Einarsdottir

Research output: Contribution to journal › Article › Research › peer-review

27 Citations (Scopus)

Abstract

Some genetic loci may affect susceptibility to multiple immune system-related diseases. In the current study, we investigated whether the known susceptibility loci for celiac disease (CelD) also associate with Crohn's disease (CD) and/or ulcerative colitis (UC), the two main forms of inflammatory bowel disease (IBD), in Finnish patients. A total of 45 genetic markers were genotyped in a Finnish data set comprising 699 IBD patients and 2482 controls. Single-marker association with IBD and its subphenotypes was tested. A meta-analysis with a Swedish UC data set was also performed. A total of 12 single-nucleotide polymorphisms associated with CD and/or UC (P<0.05). In the subphenotype analysis, rs6974491-ELMO1 (P=0.0002, odds ratio (OR): 2.20) and rs2298428-UBE2L3 (P=5.44×10^-5, OR: 2.59) associated with pediatric UC and CD, respectively. In the meta-analysis, rs4819388-ICOSLG (P=0.00042, OR: 0.79) associated with UC. In the subphenotype meta-analysis, rs1738074-TAGAP (P=7.40×10^-5, OR: 0.61), rs6974491-ELMO1 (P=0.00052, OR: 1.73) and rs4819388-ICOSLG (P=0.00019, OR: 0.75) associated with familial UC, pediatric UC and sporadic UC, respectively. Multiple CelD risk loci also confer susceptibility for CD and/or UC in the Finnish and Swedish populations. Certain genetic risk variants may furthermore predispose an individual for developing a particular disease phenotype.

Original language	English
Pages (from-to)	474-480
Number of pages	7
Journal	Genes and Immunity
Volume	13
Issue number	6
DOIs	https://doi.org/10.1038/gene.2012.21
Publication status	Published - 1 Sept 2012
Externally published	Yes

Keywords

association
celiac disease
Crohn's disease
ulcerative colitis

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10.1038/gene.2012.21

Cite this

Parmar, A. S., Lappalainen, M., Paavola-Sakki, P., Halme, L., Färkkilä, M., Turunen, U., Kontula, K., Aromaa, A., Salomaa, V., Peltonen, L., Halfvarson, J., Törkvist, L., D'Amato, M., Saavalainen, P., & Einarsdottir, E. (2012). Association of celiac disease genes with inflammatory bowel disease in Finnish and Swedish patients. Genes and Immunity, 13(6), 474-480. https://doi.org/10.1038/gene.2012.21

@article{f0a4cf8566164d9c887ee8c4e348d674,

title = "Association of celiac disease genes with inflammatory bowel disease in Finnish and Swedish patients",

abstract = "Some genetic loci may affect susceptibility to multiple immune system-related diseases. In the current study, we investigated whether the known susceptibility loci for celiac disease (CelD) also associate with Crohn's disease (CD) and/or ulcerative colitis (UC), the two main forms of inflammatory bowel disease (IBD), in Finnish patients. A total of 45 genetic markers were genotyped in a Finnish data set comprising 699 IBD patients and 2482 controls. Single-marker association with IBD and its subphenotypes was tested. A meta-analysis with a Swedish UC data set was also performed. A total of 12 single-nucleotide polymorphisms associated with CD and/or UC (P<0.05). In the subphenotype analysis, rs6974491-ELMO1 (P=0.0002, odds ratio (OR): 2.20) and rs2298428-UBE2L3 (P=5.44×10-5, OR: 2.59) associated with pediatric UC and CD, respectively. In the meta-analysis, rs4819388-ICOSLG (P=0.00042, OR: 0.79) associated with UC. In the subphenotype meta-analysis, rs1738074-TAGAP (P=7.40×10-5, OR: 0.61), rs6974491-ELMO1 (P=0.00052, OR: 1.73) and rs4819388-ICOSLG (P=0.00019, OR: 0.75) associated with familial UC, pediatric UC and sporadic UC, respectively. Multiple CelD risk loci also confer susceptibility for CD and/or UC in the Finnish and Swedish populations. Certain genetic risk variants may furthermore predispose an individual for developing a particular disease phenotype.",

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author = "Parmar, \{A. S.\} and M. Lappalainen and P. Paavola-Sakki and L. Halme and M. F{\"a}rkkil{\"a} and U. Turunen and K. Kontula and A. Aromaa and V. Salomaa and L. Peltonen and J. Halfvarson and L. T{\"o}rkvist and M. D'Amato and P. Saavalainen and E. Einarsdottir",

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Parmar, AS, Lappalainen, M, Paavola-Sakki, P, Halme, L, Färkkilä, M, Turunen, U, Kontula, K, Aromaa, A, Salomaa, V, Peltonen, L, Halfvarson, J, Törkvist, L, D'Amato, M, Saavalainen, P & Einarsdottir, E 2012, 'Association of celiac disease genes with inflammatory bowel disease in Finnish and Swedish patients', Genes and Immunity, vol. 13, no. 6, pp. 474-480. https://doi.org/10.1038/gene.2012.21

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T1 - Association of celiac disease genes with inflammatory bowel disease in Finnish and Swedish patients

AU - Parmar, A. S.

AU - Lappalainen, M.

AU - Paavola-Sakki, P.

AU - Halme, L.

AU - Färkkilä, M.

AU - Turunen, U.

AU - Kontula, K.

AU - Aromaa, A.

AU - Salomaa, V.

AU - Peltonen, L.

AU - Halfvarson, J.

AU - Törkvist, L.

AU - D'Amato, M.

AU - Saavalainen, P.

AU - Einarsdottir, E.

PY - 2012/9/1

Y1 - 2012/9/1

N2 - Some genetic loci may affect susceptibility to multiple immune system-related diseases. In the current study, we investigated whether the known susceptibility loci for celiac disease (CelD) also associate with Crohn's disease (CD) and/or ulcerative colitis (UC), the two main forms of inflammatory bowel disease (IBD), in Finnish patients. A total of 45 genetic markers were genotyped in a Finnish data set comprising 699 IBD patients and 2482 controls. Single-marker association with IBD and its subphenotypes was tested. A meta-analysis with a Swedish UC data set was also performed. A total of 12 single-nucleotide polymorphisms associated with CD and/or UC (P<0.05). In the subphenotype analysis, rs6974491-ELMO1 (P=0.0002, odds ratio (OR): 2.20) and rs2298428-UBE2L3 (P=5.44×10-5, OR: 2.59) associated with pediatric UC and CD, respectively. In the meta-analysis, rs4819388-ICOSLG (P=0.00042, OR: 0.79) associated with UC. In the subphenotype meta-analysis, rs1738074-TAGAP (P=7.40×10-5, OR: 0.61), rs6974491-ELMO1 (P=0.00052, OR: 1.73) and rs4819388-ICOSLG (P=0.00019, OR: 0.75) associated with familial UC, pediatric UC and sporadic UC, respectively. Multiple CelD risk loci also confer susceptibility for CD and/or UC in the Finnish and Swedish populations. Certain genetic risk variants may furthermore predispose an individual for developing a particular disease phenotype.

AB - Some genetic loci may affect susceptibility to multiple immune system-related diseases. In the current study, we investigated whether the known susceptibility loci for celiac disease (CelD) also associate with Crohn's disease (CD) and/or ulcerative colitis (UC), the two main forms of inflammatory bowel disease (IBD), in Finnish patients. A total of 45 genetic markers were genotyped in a Finnish data set comprising 699 IBD patients and 2482 controls. Single-marker association with IBD and its subphenotypes was tested. A meta-analysis with a Swedish UC data set was also performed. A total of 12 single-nucleotide polymorphisms associated with CD and/or UC (P<0.05). In the subphenotype analysis, rs6974491-ELMO1 (P=0.0002, odds ratio (OR): 2.20) and rs2298428-UBE2L3 (P=5.44×10-5, OR: 2.59) associated with pediatric UC and CD, respectively. In the meta-analysis, rs4819388-ICOSLG (P=0.00042, OR: 0.79) associated with UC. In the subphenotype meta-analysis, rs1738074-TAGAP (P=7.40×10-5, OR: 0.61), rs6974491-ELMO1 (P=0.00052, OR: 1.73) and rs4819388-ICOSLG (P=0.00019, OR: 0.75) associated with familial UC, pediatric UC and sporadic UC, respectively. Multiple CelD risk loci also confer susceptibility for CD and/or UC in the Finnish and Swedish populations. Certain genetic risk variants may furthermore predispose an individual for developing a particular disease phenotype.

KW - association

KW - celiac disease

KW - Crohn's disease

KW - ulcerative colitis

UR - https://www.scopus.com/pages/publications/84865634437

U2 - 10.1038/gene.2012.21

DO - 10.1038/gene.2012.21

M3 - Article

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AN - SCOPUS:84865634437

SN - 1466-4879

VL - 13

SP - 474

EP - 480

JO - Genes and Immunity

JF - Genes and Immunity

IS - 6

ER -

Association of celiac disease genes with inflammatory bowel disease in Finnish and Swedish patients

Abstract

Keywords

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