TY - JOUR
T1 - Association of arterial blood pressure and vasopressor load with septic shock mortality: a post hoc analysis of a multicenter trial
AU - Dunser, Martin
AU - Ruokonen, Esko
AU - Pettila, Ville Yrjo Olavi
AU - Ulmer, Hanno
AU - Torgersen, Christian
AU - Schmittinger, Christian
AU - Jakob, Stephan
AU - Takala, Jukka
PY - 2009
Y1 - 2009
N2 - Introduction It is unclear to which level mean arterial blood
pressure (MAP) should be increased during septic shock in
order to improve outcome. In this study we investigated the
association between MAP values of 70 mmHg or higher,
vasopressor load, 28-day mortality and disease-related events in
septic shock.
Conclusions MAP levels of 70 mmHg or higher do not appear
to be associated with improved survival in septic shock.
Elevating MAP >70 mmHg by augmenting vasopressor
dosages may increase mortality. Future trials are needed to
identify the lowest acceptable MAP level to ensure tissue
perfusion and avoid unnecessary high catecholamine infusions.
AB - Introduction It is unclear to which level mean arterial blood
pressure (MAP) should be increased during septic shock in
order to improve outcome. In this study we investigated the
association between MAP values of 70 mmHg or higher,
vasopressor load, 28-day mortality and disease-related events in
septic shock.
Conclusions MAP levels of 70 mmHg or higher do not appear
to be associated with improved survival in septic shock.
Elevating MAP >70 mmHg by augmenting vasopressor
dosages may increase mortality. Future trials are needed to
identify the lowest acceptable MAP level to ensure tissue
perfusion and avoid unnecessary high catecholamine infusions.
UR - http://ccforum.com/content/13/6/R181
U2 - 10.1186/cc8167
DO - 10.1186/cc8167
M3 - Article
SN - 1466-609X
VL - 13
SP - 1
EP - 7
JO - Critical Care
JF - Critical Care
IS - 6
ER -