Association of arterial blood pressure and vasopressor load with septic shock mortality: a post hoc analysis of a multicenter trial

Martin Dunser, Esko Ruokonen, Ville Yrjo Olavi Pettila, Hanno Ulmer, Christian Torgersen, Christian Schmittinger, Stephan Jakob, Jukka Takala

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Introduction It is unclear to which level mean arterial blood pressure (MAP) should be increased during septic shock in order to improve outcome. In this study we investigated the association between MAP values of 70 mmHg or higher, vasopressor load, 28-day mortality and disease-related events in septic shock. Conclusions MAP levels of 70 mmHg or higher do not appear to be associated with improved survival in septic shock. Elevating MAP >70 mmHg by augmenting vasopressor dosages may increase mortality. Future trials are needed to identify the lowest acceptable MAP level to ensure tissue perfusion and avoid unnecessary high catecholamine infusions.
Original languageEnglish
Pages (from-to)1 - 7
Number of pages7
JournalCritical Care
Issue number6
Publication statusPublished - 2009

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