Association of annexin V with mitochondria

Jiuru Sun, Catherina H. Bird, Hatem H. Salem, Phillip Bird

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Annexin V is an intracellular protein recently shown to be localized to nucleoli and cytosol. In this study we show that cytosolic annexin V is associated with mitochondria. To assess the nature of the annexin V-mitochondrial interaction, an annexin V binding activity was partially purified from placental cytosol by annexin V-affinity chromatography. Five polypeptides in the eluate appeared to be associated with annexin V, with a predominant species of 27 kDa. Antibodies to the 27 kDa polypeptide recognised mitochondria but not nucleoli. We conclude that annexin V interacts with a 27 kDa nutochondrial polypeptide that is possibly part of a larger complex.

Original languageEnglish
Pages (from-to)79-83
Number of pages5
JournalFEBS Letters
Issue number1-2
Publication statusPublished - 23 Aug 1993
Externally publishedYes


  • Annexin V
  • Mitochondrion

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