Abstract
Background: The association between anal high-grade squamous intraepithelial lesion (HSIL) and anal symptoms has not been systematically investigated. Methods: The Study of Prevention of Anal Cancer is a prospective cohort study of men who have sex with men (MSM) ≥ 35 years old in Sydney, Australia. Self-reported symptoms were collected. Anal cytology and high-resolution anoscopy were undertaken. Using baseline visit data, men negative for squamous intra-epithelial lesion (SIL) were compared with men diagnosed with composite-HSIL (cytology and/or histology). Logistic regression analyses were performed to assess the association of symptoms with HSIL. Results: Among 414 MSM included (composite-HSIL (n = 231); negative for SIL (n = 183)), 306 (73.9%) reported symptom(s) within the last 6 months. There was no association between any symptom and composite-HSIL. A significant association between anal lump and a larger burden of HSIL (at least 2 intra-anal octants) (anal lump within last month: p = 0.014; anal lump within last 6 months: p = 0.010) became non-significant after adjusting for HIV-status and recent anal warts (anal lump within last month: p = 0.057; anal lump within last 6 months: p = 0.182). Conclusions: Among MSM age 35 years and older, most anal symptoms are not a useful marker of anal HSIL.
| Original language | English |
|---|---|
| Pages (from-to) | 12-16 |
| Number of pages | 5 |
| Journal | Cancer Epidemiology |
| Volume | 58 |
| DOIs | |
| Publication status | Published - 1 Feb 2019 |
Keywords
- Anogenital cancer
- Anogenital conditions
- Homosexuality
- HPV
Cite this
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Association of anal symptoms with anal high grade squamous intraepithelial lesions (HSIL) among men who have sex with men : Baseline data from the study of the prevention of anal cancer (SPANC). / on behalf of the Study for the Prevention of Anal Cancer (SPANC) Research Team.
In: Cancer Epidemiology, Vol. 58, 01.02.2019, p. 12-16.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Association of anal symptoms with anal high grade squamous intraepithelial lesions (HSIL) among men who have sex with men
T2 - Baseline data from the study of the prevention of anal cancer (SPANC)
AU - Goddard, S. L.
AU - Templeton, D. J.
AU - Petoumenos, K.
AU - Jin, F.
AU - Hillman, R. J.
AU - Law, C.
AU - Roberts, J. M.
AU - Fairley, C. K.
AU - Garland, S. M.
AU - Grulich, A. E.
AU - Poynten, I. M.
AU - on behalf of the Study for the Prevention of Anal Cancer (SPANC) Research Team
PY - 2019/2/1
Y1 - 2019/2/1
N2 - Background: The association between anal high-grade squamous intraepithelial lesion (HSIL) and anal symptoms has not been systematically investigated. Methods: The Study of Prevention of Anal Cancer is a prospective cohort study of men who have sex with men (MSM) ≥ 35 years old in Sydney, Australia. Self-reported symptoms were collected. Anal cytology and high-resolution anoscopy were undertaken. Using baseline visit data, men negative for squamous intra-epithelial lesion (SIL) were compared with men diagnosed with composite-HSIL (cytology and/or histology). Logistic regression analyses were performed to assess the association of symptoms with HSIL. Results: Among 414 MSM included (composite-HSIL (n = 231); negative for SIL (n = 183)), 306 (73.9%) reported symptom(s) within the last 6 months. There was no association between any symptom and composite-HSIL. A significant association between anal lump and a larger burden of HSIL (at least 2 intra-anal octants) (anal lump within last month: p = 0.014; anal lump within last 6 months: p = 0.010) became non-significant after adjusting for HIV-status and recent anal warts (anal lump within last month: p = 0.057; anal lump within last 6 months: p = 0.182). Conclusions: Among MSM age 35 years and older, most anal symptoms are not a useful marker of anal HSIL.
AB - Background: The association between anal high-grade squamous intraepithelial lesion (HSIL) and anal symptoms has not been systematically investigated. Methods: The Study of Prevention of Anal Cancer is a prospective cohort study of men who have sex with men (MSM) ≥ 35 years old in Sydney, Australia. Self-reported symptoms were collected. Anal cytology and high-resolution anoscopy were undertaken. Using baseline visit data, men negative for squamous intra-epithelial lesion (SIL) were compared with men diagnosed with composite-HSIL (cytology and/or histology). Logistic regression analyses were performed to assess the association of symptoms with HSIL. Results: Among 414 MSM included (composite-HSIL (n = 231); negative for SIL (n = 183)), 306 (73.9%) reported symptom(s) within the last 6 months. There was no association between any symptom and composite-HSIL. A significant association between anal lump and a larger burden of HSIL (at least 2 intra-anal octants) (anal lump within last month: p = 0.014; anal lump within last 6 months: p = 0.010) became non-significant after adjusting for HIV-status and recent anal warts (anal lump within last month: p = 0.057; anal lump within last 6 months: p = 0.182). Conclusions: Among MSM age 35 years and older, most anal symptoms are not a useful marker of anal HSIL.
KW - Anogenital cancer
KW - Anogenital conditions
KW - Homosexuality
KW - HPV
UR - http://www.scopus.com/inward/record.url?scp=85056251764&partnerID=8YFLogxK
U2 - 10.1016/j.canep.2018.10.009
DO - 10.1016/j.canep.2018.10.009
M3 - Article
VL - 58
SP - 12
EP - 16
JO - Cancer Epidemiology
JF - Cancer Epidemiology
SN - 1877-7821
ER -