Association of anal symptoms with anal high grade squamous intraepithelial lesions (HSIL) among men who have sex with men: Baseline data from the study of the prevention of anal cancer (SPANC)

on behalf of the Study for the Prevention of Anal Cancer (SPANC) Research Team

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Background: The association between anal high-grade squamous intraepithelial lesion (HSIL) and anal symptoms has not been systematically investigated. Methods: The Study of Prevention of Anal Cancer is a prospective cohort study of men who have sex with men (MSM) ≥ 35 years old in Sydney, Australia. Self-reported symptoms were collected. Anal cytology and high-resolution anoscopy were undertaken. Using baseline visit data, men negative for squamous intra-epithelial lesion (SIL) were compared with men diagnosed with composite-HSIL (cytology and/or histology). Logistic regression analyses were performed to assess the association of symptoms with HSIL. Results: Among 414 MSM included (composite-HSIL (n = 231); negative for SIL (n = 183)), 306 (73.9%) reported symptom(s) within the last 6 months. There was no association between any symptom and composite-HSIL. A significant association between anal lump and a larger burden of HSIL (at least 2 intra-anal octants) (anal lump within last month: p = 0.014; anal lump within last 6 months: p = 0.010) became non-significant after adjusting for HIV-status and recent anal warts (anal lump within last month: p = 0.057; anal lump within last 6 months: p = 0.182). Conclusions: Among MSM age 35 years and older, most anal symptoms are not a useful marker of anal HSIL.

Original languageEnglish
Pages (from-to)12-16
Number of pages5
JournalCancer Epidemiology
Volume58
DOIs
Publication statusPublished - 1 Feb 2019

Keywords

  • Anogenital cancer
  • Anogenital conditions
  • Homosexuality
  • HPV

Cite this

@article{a16dfdd8f9194f77b2a86119948fb6f6,
title = "Association of anal symptoms with anal high grade squamous intraepithelial lesions (HSIL) among men who have sex with men: Baseline data from the study of the prevention of anal cancer (SPANC)",
abstract = "Background: The association between anal high-grade squamous intraepithelial lesion (HSIL) and anal symptoms has not been systematically investigated. Methods: The Study of Prevention of Anal Cancer is a prospective cohort study of men who have sex with men (MSM) ≥ 35 years old in Sydney, Australia. Self-reported symptoms were collected. Anal cytology and high-resolution anoscopy were undertaken. Using baseline visit data, men negative for squamous intra-epithelial lesion (SIL) were compared with men diagnosed with composite-HSIL (cytology and/or histology). Logistic regression analyses were performed to assess the association of symptoms with HSIL. Results: Among 414 MSM included (composite-HSIL (n = 231); negative for SIL (n = 183)), 306 (73.9{\%}) reported symptom(s) within the last 6 months. There was no association between any symptom and composite-HSIL. A significant association between anal lump and a larger burden of HSIL (at least 2 intra-anal octants) (anal lump within last month: p = 0.014; anal lump within last 6 months: p = 0.010) became non-significant after adjusting for HIV-status and recent anal warts (anal lump within last month: p = 0.057; anal lump within last 6 months: p = 0.182). Conclusions: Among MSM age 35 years and older, most anal symptoms are not a useful marker of anal HSIL.",
keywords = "Anogenital cancer, Anogenital conditions, Homosexuality, HPV",
author = "Goddard, {S. L.} and Templeton, {D. J.} and K. Petoumenos and F. Jin and Hillman, {R. J.} and C. Law and Roberts, {J. M.} and Fairley, {C. K.} and Garland, {S. M.} and Grulich, {A. E.} and Poynten, {I. M.} and {on behalf of the Study for the Prevention of Anal Cancer (SPANC) Research Team}",
year = "2019",
month = "2",
day = "1",
doi = "10.1016/j.canep.2018.10.009",
language = "English",
volume = "58",
pages = "12--16",
journal = "Cancer Epidemiology",
issn = "1877-7821",
publisher = "Elsevier",

}

Association of anal symptoms with anal high grade squamous intraepithelial lesions (HSIL) among men who have sex with men : Baseline data from the study of the prevention of anal cancer (SPANC). / on behalf of the Study for the Prevention of Anal Cancer (SPANC) Research Team.

In: Cancer Epidemiology, Vol. 58, 01.02.2019, p. 12-16.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Association of anal symptoms with anal high grade squamous intraepithelial lesions (HSIL) among men who have sex with men

T2 - Baseline data from the study of the prevention of anal cancer (SPANC)

AU - Goddard, S. L.

AU - Templeton, D. J.

AU - Petoumenos, K.

AU - Jin, F.

AU - Hillman, R. J.

AU - Law, C.

AU - Roberts, J. M.

AU - Fairley, C. K.

AU - Garland, S. M.

AU - Grulich, A. E.

AU - Poynten, I. M.

AU - on behalf of the Study for the Prevention of Anal Cancer (SPANC) Research Team

PY - 2019/2/1

Y1 - 2019/2/1

N2 - Background: The association between anal high-grade squamous intraepithelial lesion (HSIL) and anal symptoms has not been systematically investigated. Methods: The Study of Prevention of Anal Cancer is a prospective cohort study of men who have sex with men (MSM) ≥ 35 years old in Sydney, Australia. Self-reported symptoms were collected. Anal cytology and high-resolution anoscopy were undertaken. Using baseline visit data, men negative for squamous intra-epithelial lesion (SIL) were compared with men diagnosed with composite-HSIL (cytology and/or histology). Logistic regression analyses were performed to assess the association of symptoms with HSIL. Results: Among 414 MSM included (composite-HSIL (n = 231); negative for SIL (n = 183)), 306 (73.9%) reported symptom(s) within the last 6 months. There was no association between any symptom and composite-HSIL. A significant association between anal lump and a larger burden of HSIL (at least 2 intra-anal octants) (anal lump within last month: p = 0.014; anal lump within last 6 months: p = 0.010) became non-significant after adjusting for HIV-status and recent anal warts (anal lump within last month: p = 0.057; anal lump within last 6 months: p = 0.182). Conclusions: Among MSM age 35 years and older, most anal symptoms are not a useful marker of anal HSIL.

AB - Background: The association between anal high-grade squamous intraepithelial lesion (HSIL) and anal symptoms has not been systematically investigated. Methods: The Study of Prevention of Anal Cancer is a prospective cohort study of men who have sex with men (MSM) ≥ 35 years old in Sydney, Australia. Self-reported symptoms were collected. Anal cytology and high-resolution anoscopy were undertaken. Using baseline visit data, men negative for squamous intra-epithelial lesion (SIL) were compared with men diagnosed with composite-HSIL (cytology and/or histology). Logistic regression analyses were performed to assess the association of symptoms with HSIL. Results: Among 414 MSM included (composite-HSIL (n = 231); negative for SIL (n = 183)), 306 (73.9%) reported symptom(s) within the last 6 months. There was no association between any symptom and composite-HSIL. A significant association between anal lump and a larger burden of HSIL (at least 2 intra-anal octants) (anal lump within last month: p = 0.014; anal lump within last 6 months: p = 0.010) became non-significant after adjusting for HIV-status and recent anal warts (anal lump within last month: p = 0.057; anal lump within last 6 months: p = 0.182). Conclusions: Among MSM age 35 years and older, most anal symptoms are not a useful marker of anal HSIL.

KW - Anogenital cancer

KW - Anogenital conditions

KW - Homosexuality

KW - HPV

UR - http://www.scopus.com/inward/record.url?scp=85056251764&partnerID=8YFLogxK

U2 - 10.1016/j.canep.2018.10.009

DO - 10.1016/j.canep.2018.10.009

M3 - Article

VL - 58

SP - 12

EP - 16

JO - Cancer Epidemiology

JF - Cancer Epidemiology

SN - 1877-7821

ER -