Projects per year
Abstract
Background: The association between anal high-grade squamous intraepithelial lesion (HSIL) and anal symptoms has not been systematically investigated. Methods: The Study of Prevention of Anal Cancer is a prospective cohort study of men who have sex with men (MSM) ≥ 35 years old in Sydney, Australia. Self-reported symptoms were collected. Anal cytology and high-resolution anoscopy were undertaken. Using baseline visit data, men negative for squamous intra-epithelial lesion (SIL) were compared with men diagnosed with composite-HSIL (cytology and/or histology). Logistic regression analyses were performed to assess the association of symptoms with HSIL. Results: Among 414 MSM included (composite-HSIL (n = 231); negative for SIL (n = 183)), 306 (73.9%) reported symptom(s) within the last 6 months. There was no association between any symptom and composite-HSIL. A significant association between anal lump and a larger burden of HSIL (at least 2 intra-anal octants) (anal lump within last month: p = 0.014; anal lump within last 6 months: p = 0.010) became non-significant after adjusting for HIV-status and recent anal warts (anal lump within last month: p = 0.057; anal lump within last 6 months: p = 0.182). Conclusions: Among MSM age 35 years and older, most anal symptoms are not a useful marker of anal HSIL.
Original language | English |
---|---|
Pages (from-to) | 12-16 |
Number of pages | 5 |
Journal | Cancer Epidemiology |
Volume | 58 |
DOIs | |
Publication status | Published - 1 Feb 2019 |
Keywords
- Anogenital cancer
- Anogenital conditions
- Homosexuality
- HPV
Projects
- 1 Finished
-
Sexually Transmitted Infections: Causes, Consequences and Interventions
Fairley, C. (Primary Chief Investigator (PCI))
National Health and Medical Research Council (NHMRC) (Australia)
1/01/13 → 31/12/14
Project: Research