TY - JOUR
T1 - Association of ABO blood group with respiratory disease hospitalization and severe outcomes
T2 - a retrospective cohort study in blood donors
AU - Su, Shu
AU - Guo, Lingxia
AU - Ma, Ting
AU - Sun, Yang
AU - Song, Aowei
AU - Wang, Wenhua
AU - Gu, Xiaoyun
AU - Wu, Wenjie
AU - Xie, Xinxin
AU - Zhang, Leilei
AU - Zhang, Lei
AU - Yang, Jiangcun
N1 - Funding Information:
Lei Zhang is supported by the National Natural Science Foundation of China (Grant number: 81950410639); Outstanding Young Scholars Support Program (Grant number: 3111500001); Xi'an Jiaotong University Basic Research and Profession Grant (Grant number: xtr022019003, xzy032020032); Epidemiology modeling and risk assessment (Grant number: 20200344); and Xi'an Jiaotong University Young Scholar Support Grant (Grant number: YX6J004). Jiangcun Yang is supported by the 2021 Science and Technology Talent Support Program of Shaanxi Provincial People's Hospital (Grant Number: 2021LJ-14). Shu Su is supported by the 2022 Science and Technology Talent Support Program of The Second Affiliated Hospital of ChongQing Medical University (Grant Number: 2022ssky). We thank the following individuals at Shaanxi Provincial Blood Center: Hengxin Li, Xiaoli Cao, and Zhendong Sun. We also acknowledge the data interpretation assistance of Ke Ding at Hanzhong blood center, Bing Shi at Yanan blood center, Erqin Bai at Yulin blood center, Shengli Yan at Weinan blood center, Guoqiang Zhang at Tongchuan blood center, Hailin Zhang at Baoji blood center, Zhangxue Hu at Ankang blood center, Guancheng Yuan at Shangluo blood center, Xin liang at Xianyang blood center, and Keqian Cheng at Shaanxi Health Information Center.
Funding Information:
Lei Zhang is supported by the National Natural Science Foundation of China (Grant number: 81950410639); Outstanding Young Scholars Support Program (Grant number: 3111500001); Xi'an Jiaotong University Basic Research and Profession Grant (Grant number: xtr022019003, xzy032020032); Epidemiology modeling and risk assessment (Grant number: 20200344); and Xi'an Jiaotong University Young Scholar Support Grant (Grant number: YX6J004). Jiangcun Yang is supported by the 2021 Science and Technology Talent Support Program of Shaanxi Provincial People's Hospital (Grant Number: 2021LJ-14). Shu Su is supported by the 2022 Science and Technology Talent Support Program of The Second Affiliated Hospital of ChongQing Medical University (Grant Number: 2022ssky).
Publisher Copyright:
© 2022 The Authors
PY - 2022/9
Y1 - 2022/9
N2 - Objectives: Environmental, socioeconomic, and genetic factors all are associated with respiratory diseases. We aimed to investigate the association between the ABO blood group and the susceptibility to respiratory diseases. Methods: We constructed a retrospective cohort study of blood donors in Shaanxi, China between January 1, 2012, and December 31, 2018, to investigate the impacts of the ABO blood group on the risk of hospitalization due to respiratory diseases. Results: Of 1,686,263 enrolled participants (680,788 females), 26,597 were admitted to the hospital for respiratory diseases. Compared with blood group O, blood groups A, B, and AB all demonstrated a higher risk for diseases of the upper respiratory tract (International Classification of Diseases, Tenth Revision: J30–J39) (ARR (Adjusted relative risk) 1.139, 95% confidence interval [1.106–1.225]; 1.095 [1.019–1.177]; 1.178 [1.067–1.30], respectively). Conversely, blood group A was found to have a lower risk (0.86 [0.747–0.991]) for influenza (J09–J11) and blood group B had a lower risk for pneumonia (J12–J18) (0.911 [0.851–0.976]) than blood group O. The duration of hospitalization was significantly different across the blood groups in J09–J11 and J30–J39 (P <0.05). Conclusion: The blood group appears to be a prognostic factor in differentiating the occurrence of specific respiratory diseases and duration.
AB - Objectives: Environmental, socioeconomic, and genetic factors all are associated with respiratory diseases. We aimed to investigate the association between the ABO blood group and the susceptibility to respiratory diseases. Methods: We constructed a retrospective cohort study of blood donors in Shaanxi, China between January 1, 2012, and December 31, 2018, to investigate the impacts of the ABO blood group on the risk of hospitalization due to respiratory diseases. Results: Of 1,686,263 enrolled participants (680,788 females), 26,597 were admitted to the hospital for respiratory diseases. Compared with blood group O, blood groups A, B, and AB all demonstrated a higher risk for diseases of the upper respiratory tract (International Classification of Diseases, Tenth Revision: J30–J39) (ARR (Adjusted relative risk) 1.139, 95% confidence interval [1.106–1.225]; 1.095 [1.019–1.177]; 1.178 [1.067–1.30], respectively). Conversely, blood group A was found to have a lower risk (0.86 [0.747–0.991]) for influenza (J09–J11) and blood group B had a lower risk for pneumonia (J12–J18) (0.911 [0.851–0.976]) than blood group O. The duration of hospitalization was significantly different across the blood groups in J09–J11 and J30–J39 (P <0.05). Conclusion: The blood group appears to be a prognostic factor in differentiating the occurrence of specific respiratory diseases and duration.
KW - ABO blood group
KW - Cohort study
KW - Duration of hospitalization
KW - Hospitalization disease–category
KW - Respiratory diseases
UR - http://www.scopus.com/inward/record.url?scp=85132398475&partnerID=8YFLogxK
U2 - 10.1016/j.ijid.2022.05.019
DO - 10.1016/j.ijid.2022.05.019
M3 - Article
C2 - 35562043
AN - SCOPUS:85132398475
VL - 122
SP - 21
EP - 29
JO - International Journal of Infectious Diseases
JF - International Journal of Infectious Diseases
SN - 1201-9712
ER -