Association between viscoelastic tests-guided therapy with synthetic factor concentrates and allogenic blood transfusion in liver transplantation: A before-after study

Raffael P.C. Zamper, Thiago C. Amorim, Veronica N.F. Queiroz, Jordana D.O. Lira, Luiz Guilherme V. Costa, Flavio Takaoka, Nicole P. Juffermans, Ary S. Neto

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Background: Perioperative bleeding and transfusion are important causes of morbidity and mortality in patients undergoing liver transplantation. The aim of this study is to assess whether viscoelastic tests-guided therapy with the use of synthetic factor concentrates impact transfusion rates of hemocomponents in adult patients undergoing liver transplantation. Methods: This is an interventional before-after comparative study. Patients undergoing liver transplantation before the implementation of a protocol using thromboelastometry and synthetic factor concentrates were compared to patients after the implementation. Primary outcome was transfusion of any hemocomponents. Secondary outcomes included: transfusion of red blood cells (RBC), fresh frozen plasma (FFP), cryoprecipitate or platelets, clinical complications, length of stay and in-hospital mortality. Results: A total of 183 patients were included in the control and 54 in the intervention phase. After propensity score matching, the proportion of patients receiving any transfusion of hemocomponents was lower in the intervention phase (37.0 vs 58.4%; OR, 0.42; 95% CI, 0.20-0.87; p = 0.019). Patients in the intervention phase received less RBC (30.2 vs 52.5%; OR, 0.21; 95% CI, 0.08-0.56; p = 0.002) and FFP (5.7 vs 27.3%; OR, 0.11; 95% CI, 0.03-0.43; p = 0.002). There was no difference regarding transfusion of cryoprecipitate and platelets, complications related to the procedure, hospital length of stay and mortality. Conclusions: Use of a viscoelastic test-guided transfusion algorithm with the use of synthetic factor concentrates reduces the transfusion rates of allogenic blood in patients submitted to liver transplantation. Trial registration: This trial was registered retrospectively on November 15th, 2018 - - Identifier: NCT03756948.

Original languageEnglish
Article number198
Number of pages12
JournalBMC Anesthesiology
Issue number1
Publication statusPublished - 22 Dec 2018
Externally publishedYes


  • Blood coagulation disorders
  • Blood transfusion
  • Fibrinogen
  • Hemorrhage
  • Hemostasis
  • Liver transplantation
  • Prothrombin complex concentrate

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