Association between the angiotensin-converting enzyme gene insertion/deletion polymorphism and essential hypertension in young Pakistani patients

Muhammad Ismail, Naveed Akhtar, Muhammad Nasir, Sadaf Firasat, Qasim Ayub, Shagufta Khaliq

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31 Citations (Scopus)

Abstract

Several studies have demonstrated the importance of angiotensin-converting enzyme (ACE) insertion (I)/deletion (D) polymorphisms in the pathogenesis of hypertension. This study sought to determine the association between the ACE I/D polymorphism and essential hypertension in young Pakistanis. The frequency of the ACE I/D polymorphism was established by a comparative cross-sectional survey of Pakistani patients suffering from essential hypertension and ethnically matched normotensive controls. Samples were collected from tertiary care hospitals in northern Pakistan. Hypertensive individuals were defined as those with a systolic blood pressure > 140 mmHg and/or diastolic blood pressure > 90 mmHg on three separate occasions, or those currently receiving one, or more, anti-hypertensive agents. DNA samples obtained from hypertensive (n = 211) and normotensive (n = 108) individuals were typed by PCR. The frequency of the ACE I/I genotype was significantly higher in hypertensive patients, aged 20-40 years, than in normotensive controls of the same age group (χ2 = 4.0, P = 0.041). Whereas no overall significant differences were observed between the I/I, I/D and D/D ACE genotypes (One way ANOVA, F = 0.672; P = 0.413). The association between the ACE I/I genotype and essential hypertension in individuals aged ≤ 40 years suggests that ACE has a role in early onset essential hypertension in Pakistan.

Original languageEnglish
Pages (from-to)552-555
Number of pages4
JournalJournal of Biochemistry and Molecular Biology
Volume37
Issue number5
DOIs
Publication statusPublished - Sept 2004
Externally publishedYes

Keywords

  • ACE I/D polymorphism
  • Angiotensin-converting enzyme
  • Cross-sectional survey
  • Essential hypertension
  • Pakistani population

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