TY - JOUR
T1 - Association Between Symptoms and Severity of Disease in Hospitalised Novel Coronavirus (COVID-19) Patients
T2 - A Systematic Review and Meta-Analysis
AU - Talukder, Ashis
AU - Razu, Shaharior Rahman
AU - Alif, Sheikh Mohammad
AU - Rahman, Muhammad Aziz
AU - Islam, Sheikh Mohammed Shariful
N1 - Funding Information:
SMSI is funded by a senior research fellowship from the Institute for Physical Activity and Nutrition (IPAN), Deakin University and a post-doctorate fellowship from the National Heart Foundation of Australia and received a career transition grant from the High Blood Pressure Research Council of Australia.
Publisher Copyright:
© 2022 Talukder et al.
PY - 2022
Y1 - 2022
N2 - Background: Symptoms of the novel coronavirus disease (COVD-19) are well known, although asymptomatic cases were also reported due to this rapidly evolving viral disease. However, there has been limited research with inconsistent findings on symptoms of COVID-19 and disease severity. We aimed to evaluate the association between symptoms and severity of disease in adult patients with confirmed COVID-19 by performing a meta-analysis. Methods: We conducted this study by searching four online databases (Medline, Web of Science, EMBASE and Cochrane library) of published studies that included symptoms of COVID-19 cases and severity of the disease between January 1, 2020, and October 31, 2021. PRISMA and MOOSE guidelines were followed, and only articles published in English were selected. We performed meta-analysis using Mantel-Haenszel random-effects model. Note that we included peer-reviewed studies conducted in Wuhan and published in the English language that reported the clinical characteristics of COVID-19, particularly the symptoms of novel coronavirus patients with their prevalence and distribution of patients based on the severity of the disease. Results: Out of 255 articles identified, a total of twenty articles, including 5390 participants, met the inclusion criteria and were included. Among the participants, 2997 (55.60%) were males, and 974 (18.07%) reported severe conditions. Fever was the most commonly reported symptom in the reported COVID-19 confirmed cases (88.47%, 95% CI: 80.74–93.35%), which was followed by cough, fatigue, and less proportionally dyspnea and myalgia. Dyspnea was the only symptom, which was associated with severity of COVID-19 (OR 2.43, 95% CI: 1.52–3.89). Conclusion: Dyspnoea was found to be associated with severity of COVID-19. People with existing respiratory illnesses, such as chronic obstructive pulmonary diseases need to be careful about the onset of such symptom and should seek medical attention.
AB - Background: Symptoms of the novel coronavirus disease (COVD-19) are well known, although asymptomatic cases were also reported due to this rapidly evolving viral disease. However, there has been limited research with inconsistent findings on symptoms of COVID-19 and disease severity. We aimed to evaluate the association between symptoms and severity of disease in adult patients with confirmed COVID-19 by performing a meta-analysis. Methods: We conducted this study by searching four online databases (Medline, Web of Science, EMBASE and Cochrane library) of published studies that included symptoms of COVID-19 cases and severity of the disease between January 1, 2020, and October 31, 2021. PRISMA and MOOSE guidelines were followed, and only articles published in English were selected. We performed meta-analysis using Mantel-Haenszel random-effects model. Note that we included peer-reviewed studies conducted in Wuhan and published in the English language that reported the clinical characteristics of COVID-19, particularly the symptoms of novel coronavirus patients with their prevalence and distribution of patients based on the severity of the disease. Results: Out of 255 articles identified, a total of twenty articles, including 5390 participants, met the inclusion criteria and were included. Among the participants, 2997 (55.60%) were males, and 974 (18.07%) reported severe conditions. Fever was the most commonly reported symptom in the reported COVID-19 confirmed cases (88.47%, 95% CI: 80.74–93.35%), which was followed by cough, fatigue, and less proportionally dyspnea and myalgia. Dyspnea was the only symptom, which was associated with severity of COVID-19 (OR 2.43, 95% CI: 1.52–3.89). Conclusion: Dyspnoea was found to be associated with severity of COVID-19. People with existing respiratory illnesses, such as chronic obstructive pulmonary diseases need to be careful about the onset of such symptom and should seek medical attention.
KW - coronavirus
KW - COVID-19
KW - respiratory
KW - severity
KW - symptoms
UR - http://www.scopus.com/inward/record.url?scp=85130435668&partnerID=8YFLogxK
U2 - 10.2147/JMDH.S357867
DO - 10.2147/JMDH.S357867
M3 - Article
C2 - 35592814
AN - SCOPUS:85130435668
SN - 1178-2390
VL - 15
SP - 1101
EP - 1110
JO - Journal of Multidisciplinary Healthcare
JF - Journal of Multidisciplinary Healthcare
ER -