Association between static and dynamic thenar near-infrared spectroscopy and mortality in patients with sepsis: A systematic review and meta-analysis

Ary Serpa Neto, Victor Galvão Moura Pereira, José Antônio Manetta, Daniel Crepaldi Espósito, Marcus J. Schultz

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36 Citations (Scopus)


BACKGROUND: Oxygen delivery and consumption disturbances are frequently seen with critically illness, potentially leading to pathologic changes in tissue oxygenation (StO2). Near-infrared spectroscopy (NIRS) is a potentially useful method to monitor StO2, but the role of NIRS in prognostication of septic patients is uncertain. The aim of this study was to systematically review the literature and evaluate static and dynamic NIRS in patients with sepsis. METHODS: This is a systematic review and meta-analysis of publications between 1966 and 2013. The MEDLINE and EMBASE databases were searched for studies on StO2 in patients with severe sepsis or septic shock. Meta-analysis was limited to studies about static and dynamic variables derived from NIRS in patients with sepsis. The association between StO 2, reperfusion slope (Rres), occlusion slope, and maximum StO 2 minus basal StO2 (δStO2) and prognosis in septic patients was evaluated. RESULTS: The search identified 20 articles (962 participants; 717 with severe sepsis or septic shock, and 245 healthy controls). Compared with healthy controls, septic patients had lower levels of StO2 (78.27% [4.91%] vs. 82.02% [3.57%], p = 0.012), Rres (2.75% [0.63%] vs. 5.19% [2.86%] per second, p = 0.003), and δStO2 (7.86% [0.11%] vs. 12.53% [2.65%], p = 0.011). Survivors from sepsis presents higher levels of StO2 (81.68% [4.68%] vs. 74.54% [5.31%], p = 0.02) and Rres (3.37% [0.44%] vs. 2.16% [0.51%] per second, p = 0.016). CONCLUSION: Septic patients have lower levels of StO2, Rres and δStO 2, and survivors from sepsis present higher levels of StO2 and Rres compared with nonsurvivors.

Original languageEnglish
Pages (from-to)226-233
Number of pages8
JournalThe Journal of Trauma and Acute Care Surgery
Issue number1
Publication statusPublished - Jan 2014
Externally publishedYes


  • Microcirculation
  • Mortality
  • NIRS
  • Sepsis
  • Tissue oxygenation

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