Abstract
Objectives: There is ongoing debate regarding the optimal serum concentrations of 25-hydroxy-vitamin D for musculoskeletal health, including osteoarthritis (OA). The aim of this prospective cohort study was to determine whether serum 25-hydroxy-vitamin D concentrations were associated with the risk of hip arthroplasty for OA. Design: This study examined 9135 participants from the Australian Diabetes, Obesity and Lifestyle Study who had serum 25-hydroxy-vitamin D measured in 1999-2000 and were aged ≥40 years at the commencement of arthroplasty data collection. The incidence of hip arthroplasty for OA during 2002-2011 was determined by linking cohort records to the Australian Orthopaedic Association National Joint Replacement Registry. Results: Over an average 9.1 (standard deviation (SD) 2.7) years of follow-up, 201 hip arthroplasties for OA were identified (males n = 90; females n = 111). In males, a one-standard-deviation increase in 25-hydroxy-vitamin D was associated with a 25% increased incidence (HR 1.25, 95% CI 1.02-1.56), with a dose response relationship evident by quartiles of 25-hydroxy-vitamin D concentration (P for trend 0.04). These results were independent of age, body mass index (BMI), ethnicity, smoking status, physical activity, season of blood collection, latitude, hypertension and diabetes, area level disadvantage or after excluding those with extreme low 25-hydroxy-vitamin D concentrations. No significant association was observed in women (HR 1.10, 95% CI 0.87, 1.39). Conclusions: Increasing serum 25-hydroxy-vitamin D concentrations were associated with an increased risk of hip arthroplasty for OA in males, while no significant association was observed in females. The mechanism for the association warrants further investigation.
| Original language | English |
|---|---|
| Pages (from-to) | 2134-2140 |
| Number of pages | 7 |
| Journal | Osteoarthritis and Cartilage |
| Volume | 23 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - 1 Dec 2015 |
Keywords
- 25-Hydroxy-vitamin D
- Hip arthroplasty
- Osteoarthritis
Cite this
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Association between serum concentration of 25-hydroxyvitamin D and the risk of hip arthroplasty for osteoarthritis : Result from a prospective cohort study. / Hussain, Mariam Sogra; Daly, Robin M; Wang, YuanYuan; Shaw, Jonathan Edward; Magliano, Dianna Josephine; Graves, Stephen E; Ebeling, Peter Robert; Wluka, Anita Estelle; Cicuttini, Flavia Maria.
In: Osteoarthritis and Cartilage, Vol. 23, No. 12, 01.12.2015, p. 2134-2140.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Association between serum concentration of 25-hydroxyvitamin D and the risk of hip arthroplasty for osteoarthritis
T2 - Result from a prospective cohort study
AU - Hussain, Mariam Sogra
AU - Daly, Robin M
AU - Wang, YuanYuan
AU - Shaw, Jonathan Edward
AU - Magliano, Dianna Josephine
AU - Graves, Stephen E
AU - Ebeling, Peter Robert
AU - Wluka, Anita Estelle
AU - Cicuttini, Flavia Maria
PY - 2015/12/1
Y1 - 2015/12/1
N2 - Objectives: There is ongoing debate regarding the optimal serum concentrations of 25-hydroxy-vitamin D for musculoskeletal health, including osteoarthritis (OA). The aim of this prospective cohort study was to determine whether serum 25-hydroxy-vitamin D concentrations were associated with the risk of hip arthroplasty for OA. Design: This study examined 9135 participants from the Australian Diabetes, Obesity and Lifestyle Study who had serum 25-hydroxy-vitamin D measured in 1999-2000 and were aged ≥40 years at the commencement of arthroplasty data collection. The incidence of hip arthroplasty for OA during 2002-2011 was determined by linking cohort records to the Australian Orthopaedic Association National Joint Replacement Registry. Results: Over an average 9.1 (standard deviation (SD) 2.7) years of follow-up, 201 hip arthroplasties for OA were identified (males n = 90; females n = 111). In males, a one-standard-deviation increase in 25-hydroxy-vitamin D was associated with a 25% increased incidence (HR 1.25, 95% CI 1.02-1.56), with a dose response relationship evident by quartiles of 25-hydroxy-vitamin D concentration (P for trend 0.04). These results were independent of age, body mass index (BMI), ethnicity, smoking status, physical activity, season of blood collection, latitude, hypertension and diabetes, area level disadvantage or after excluding those with extreme low 25-hydroxy-vitamin D concentrations. No significant association was observed in women (HR 1.10, 95% CI 0.87, 1.39). Conclusions: Increasing serum 25-hydroxy-vitamin D concentrations were associated with an increased risk of hip arthroplasty for OA in males, while no significant association was observed in females. The mechanism for the association warrants further investigation.
AB - Objectives: There is ongoing debate regarding the optimal serum concentrations of 25-hydroxy-vitamin D for musculoskeletal health, including osteoarthritis (OA). The aim of this prospective cohort study was to determine whether serum 25-hydroxy-vitamin D concentrations were associated with the risk of hip arthroplasty for OA. Design: This study examined 9135 participants from the Australian Diabetes, Obesity and Lifestyle Study who had serum 25-hydroxy-vitamin D measured in 1999-2000 and were aged ≥40 years at the commencement of arthroplasty data collection. The incidence of hip arthroplasty for OA during 2002-2011 was determined by linking cohort records to the Australian Orthopaedic Association National Joint Replacement Registry. Results: Over an average 9.1 (standard deviation (SD) 2.7) years of follow-up, 201 hip arthroplasties for OA were identified (males n = 90; females n = 111). In males, a one-standard-deviation increase in 25-hydroxy-vitamin D was associated with a 25% increased incidence (HR 1.25, 95% CI 1.02-1.56), with a dose response relationship evident by quartiles of 25-hydroxy-vitamin D concentration (P for trend 0.04). These results were independent of age, body mass index (BMI), ethnicity, smoking status, physical activity, season of blood collection, latitude, hypertension and diabetes, area level disadvantage or after excluding those with extreme low 25-hydroxy-vitamin D concentrations. No significant association was observed in women (HR 1.10, 95% CI 0.87, 1.39). Conclusions: Increasing serum 25-hydroxy-vitamin D concentrations were associated with an increased risk of hip arthroplasty for OA in males, while no significant association was observed in females. The mechanism for the association warrants further investigation.
KW - 25-Hydroxy-vitamin D
KW - Hip arthroplasty
KW - Osteoarthritis
UR - http://www.scopus.com/inward/record.url?scp=84960272595&partnerID=8YFLogxK
U2 - 10.1016/j.joca.2015.06.006
DO - 10.1016/j.joca.2015.06.006
M3 - Article
VL - 23
SP - 2134
EP - 2140
JO - Osteoarthritis and Cartilage
JF - Osteoarthritis and Cartilage
SN - 1063-4584
IS - 12
ER -