Abstract
METHODS: 261 participants (mean age 63.0 ± 7.2 years) with symptomatic knee OA were selected from a randomized controlled trial with a follow up of 2 years. IPFP signal intensity alterations at baseline were quantitatively measured on T2-weighted fat-saturated MRI using MATLAB. These quantitative measures included the standard deviation [sDev (IPFP)] of whole IPFP signal intensity, the upper quartile value [UQ (H)] of high signal intensity, the ratio of volume of high signal intensity alteration to volume of whole IPFP [Percentage (H)] and Clustering factor (H) representing the clustering effect of high signal intensity. Cartilage volume and defects, and BMLs were assessed using validated measures RESULTS: Higher baseline sDev (IPFP), UQ (H) and Clustering factor (H) were associated with greater loss of tibial cartilage volume and larger increases in tibiofemoral cartilage defects over 2 years. Patients with high and medium tertiles of Clustering factor (H) had greater loss of cartilage volume per annum compared with those with low tertile (4.9% and 4.6% vs 3.3% p.a.). Baseline Percentage (H) and Clustering factor (H) were positively and significantly associated with increases in tibiofemoral BMLs over 2 years. Cross-sectional associations between IPFP measures and knee structures were similar but more consistent.
CONCLUSION: Quantitative measures of increased signal intensity in the IPFP were associated with knee structural abnormalities in tibiofemoral compartment, suggesting that these measurements could be used as an additional entry criteria in order to enrich for 'faster progressors' in studies of knee OA.
| Original language | English |
|---|---|
| Pages (from-to) | 638-646 |
| Number of pages | 9 |
| Journal | Arthritis Care and Research |
| Volume | 71 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - May 2019 |
Cite this
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Association between quantitatively measured infrapatellar fat pad high signal intensity alteration and MRI-assessed progression of knee osteoarthritis. / Han, Weiyu; Aitken, Dawn; Zheng, Shuang; Wluka, Anita Estelle; Zhu, Z.; Blizzard, Leigh; Winzenberg, Tania Maree; Cicuttini, Flavia Maria; Jones, Graeme; Ding, Changhai.
In: Arthritis Care and Research, Vol. 71, No. 5, 05.2019, p. 638-646.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Association between quantitatively measured infrapatellar fat pad high signal intensity alteration and MRI-assessed progression of knee osteoarthritis
AU - Han, Weiyu
AU - Aitken, Dawn
AU - Zheng, Shuang
AU - Wluka, Anita Estelle
AU - Zhu, Z.
AU - Blizzard, Leigh
AU - Winzenberg, Tania Maree
AU - Cicuttini, Flavia Maria
AU - Jones, Graeme
AU - Ding, Changhai
PY - 2019/5
Y1 - 2019/5
N2 - OBJECTIVE: To describe the cross-sectional and longitudinal associations between quantitative measures of infrapatellar fat pad (IPFP) signal intensity alteration and knee structural abnormalities in patients with symptomatic knee OA.METHODS: 261 participants (mean age 63.0 ± 7.2 years) with symptomatic knee OA were selected from a randomized controlled trial with a follow up of 2 years. IPFP signal intensity alterations at baseline were quantitatively measured on T2-weighted fat-saturated MRI using MATLAB. These quantitative measures included the standard deviation [sDev (IPFP)] of whole IPFP signal intensity, the upper quartile value [UQ (H)] of high signal intensity, the ratio of volume of high signal intensity alteration to volume of whole IPFP [Percentage (H)] and Clustering factor (H) representing the clustering effect of high signal intensity. Cartilage volume and defects, and BMLs were assessed using validated measures RESULTS: Higher baseline sDev (IPFP), UQ (H) and Clustering factor (H) were associated with greater loss of tibial cartilage volume and larger increases in tibiofemoral cartilage defects over 2 years. Patients with high and medium tertiles of Clustering factor (H) had greater loss of cartilage volume per annum compared with those with low tertile (4.9% and 4.6% vs 3.3% p.a.). Baseline Percentage (H) and Clustering factor (H) were positively and significantly associated with increases in tibiofemoral BMLs over 2 years. Cross-sectional associations between IPFP measures and knee structures were similar but more consistent.CONCLUSION: Quantitative measures of increased signal intensity in the IPFP were associated with knee structural abnormalities in tibiofemoral compartment, suggesting that these measurements could be used as an additional entry criteria in order to enrich for 'faster progressors' in studies of knee OA.
AB - OBJECTIVE: To describe the cross-sectional and longitudinal associations between quantitative measures of infrapatellar fat pad (IPFP) signal intensity alteration and knee structural abnormalities in patients with symptomatic knee OA.METHODS: 261 participants (mean age 63.0 ± 7.2 years) with symptomatic knee OA were selected from a randomized controlled trial with a follow up of 2 years. IPFP signal intensity alterations at baseline were quantitatively measured on T2-weighted fat-saturated MRI using MATLAB. These quantitative measures included the standard deviation [sDev (IPFP)] of whole IPFP signal intensity, the upper quartile value [UQ (H)] of high signal intensity, the ratio of volume of high signal intensity alteration to volume of whole IPFP [Percentage (H)] and Clustering factor (H) representing the clustering effect of high signal intensity. Cartilage volume and defects, and BMLs were assessed using validated measures RESULTS: Higher baseline sDev (IPFP), UQ (H) and Clustering factor (H) were associated with greater loss of tibial cartilage volume and larger increases in tibiofemoral cartilage defects over 2 years. Patients with high and medium tertiles of Clustering factor (H) had greater loss of cartilage volume per annum compared with those with low tertile (4.9% and 4.6% vs 3.3% p.a.). Baseline Percentage (H) and Clustering factor (H) were positively and significantly associated with increases in tibiofemoral BMLs over 2 years. Cross-sectional associations between IPFP measures and knee structures were similar but more consistent.CONCLUSION: Quantitative measures of increased signal intensity in the IPFP were associated with knee structural abnormalities in tibiofemoral compartment, suggesting that these measurements could be used as an additional entry criteria in order to enrich for 'faster progressors' in studies of knee OA.
UR - https://www-scopus-com.ezproxy.lib.monash.edu.au/record/display.uri?eid=2-s2.0-85064839513&origin=resultslist
U2 - 10.1002/acr.23713
DO - 10.1002/acr.23713
M3 - Article
VL - 71
SP - 638
EP - 646
JO - Arthritis Care and Research
JF - Arthritis Care and Research
SN - 2151-464X
IS - 5
ER -