Association between quantitatively measured infrapatellar fat pad high signal intensity alteration and MRI-assessed progression of knee osteoarthritis

Weiyu Han, Dawn Aitken, Shuang Zheng, Anita Estelle Wluka, Z. Zhu, Leigh Blizzard, Tania Maree Winzenberg, Flavia Maria Cicuttini, Graeme Jones, Changhai Ding

Research output: Contribution to journalArticleResearchpeer-review

Abstract

OBJECTIVE: To describe the cross-sectional and longitudinal associations between quantitative measures of infrapatellar fat pad (IPFP) signal intensity alteration and knee structural abnormalities in patients with symptomatic knee OA.

METHODS: 261 participants (mean age 63.0 ± 7.2 years) with symptomatic knee OA were selected from a randomized controlled trial with a follow up of 2 years. IPFP signal intensity alterations at baseline were quantitatively measured on T2-weighted fat-saturated MRI using MATLAB. These quantitative measures included the standard deviation [sDev (IPFP)] of whole IPFP signal intensity, the upper quartile value [UQ (H)] of high signal intensity, the ratio of volume of high signal intensity alteration to volume of whole IPFP [Percentage (H)] and Clustering factor (H) representing the clustering effect of high signal intensity. Cartilage volume and defects, and BMLs were assessed using validated measures RESULTS: Higher baseline sDev (IPFP), UQ (H) and Clustering factor (H) were associated with greater loss of tibial cartilage volume and larger increases in tibiofemoral cartilage defects over 2 years. Patients with high and medium tertiles of Clustering factor (H) had greater loss of cartilage volume per annum compared with those with low tertile (4.9% and 4.6% vs 3.3% p.a.). Baseline Percentage (H) and Clustering factor (H) were positively and significantly associated with increases in tibiofemoral BMLs over 2 years. Cross-sectional associations between IPFP measures and knee structures were similar but more consistent.

CONCLUSION: Quantitative measures of increased signal intensity in the IPFP were associated with knee structural abnormalities in tibiofemoral compartment, suggesting that these measurements could be used as an additional entry criteria in order to enrich for 'faster progressors' in studies of knee OA.
Original languageEnglish
Pages (from-to)638-646
Number of pages9
JournalArthritis Care and Research
Volume71
Issue number5
DOIs
Publication statusPublished - May 2019

Cite this

@article{4bdd9ae6d4614c68b3e4c538b87b3a9a,
title = "Association between quantitatively measured infrapatellar fat pad high signal intensity alteration and MRI-assessed progression of knee osteoarthritis",
abstract = "OBJECTIVE: To describe the cross-sectional and longitudinal associations between quantitative measures of infrapatellar fat pad (IPFP) signal intensity alteration and knee structural abnormalities in patients with symptomatic knee OA.METHODS: 261 participants (mean age 63.0 ± 7.2 years) with symptomatic knee OA were selected from a randomized controlled trial with a follow up of 2 years. IPFP signal intensity alterations at baseline were quantitatively measured on T2-weighted fat-saturated MRI using MATLAB. These quantitative measures included the standard deviation [sDev (IPFP)] of whole IPFP signal intensity, the upper quartile value [UQ (H)] of high signal intensity, the ratio of volume of high signal intensity alteration to volume of whole IPFP [Percentage (H)] and Clustering factor (H) representing the clustering effect of high signal intensity. Cartilage volume and defects, and BMLs were assessed using validated measures RESULTS: Higher baseline sDev (IPFP), UQ (H) and Clustering factor (H) were associated with greater loss of tibial cartilage volume and larger increases in tibiofemoral cartilage defects over 2 years. Patients with high and medium tertiles of Clustering factor (H) had greater loss of cartilage volume per annum compared with those with low tertile (4.9{\%} and 4.6{\%} vs 3.3{\%} p.a.). Baseline Percentage (H) and Clustering factor (H) were positively and significantly associated with increases in tibiofemoral BMLs over 2 years. Cross-sectional associations between IPFP measures and knee structures were similar but more consistent.CONCLUSION: Quantitative measures of increased signal intensity in the IPFP were associated with knee structural abnormalities in tibiofemoral compartment, suggesting that these measurements could be used as an additional entry criteria in order to enrich for 'faster progressors' in studies of knee OA.",
author = "Weiyu Han and Dawn Aitken and Shuang Zheng and Wluka, {Anita Estelle} and Z. Zhu and Leigh Blizzard and Winzenberg, {Tania Maree} and Cicuttini, {Flavia Maria} and Graeme Jones and Changhai Ding",
year = "2019",
month = "5",
doi = "10.1002/acr.23713",
language = "English",
volume = "71",
pages = "638--646",
journal = "Arthritis Care and Research",
issn = "2151-464X",
publisher = "Wiley-Blackwell",
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}

Association between quantitatively measured infrapatellar fat pad high signal intensity alteration and MRI-assessed progression of knee osteoarthritis. / Han, Weiyu; Aitken, Dawn; Zheng, Shuang; Wluka, Anita Estelle; Zhu, Z.; Blizzard, Leigh; Winzenberg, Tania Maree; Cicuttini, Flavia Maria; Jones, Graeme; Ding, Changhai.

In: Arthritis Care and Research, Vol. 71, No. 5, 05.2019, p. 638-646.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Association between quantitatively measured infrapatellar fat pad high signal intensity alteration and MRI-assessed progression of knee osteoarthritis

AU - Han, Weiyu

AU - Aitken, Dawn

AU - Zheng, Shuang

AU - Wluka, Anita Estelle

AU - Zhu, Z.

AU - Blizzard, Leigh

AU - Winzenberg, Tania Maree

AU - Cicuttini, Flavia Maria

AU - Jones, Graeme

AU - Ding, Changhai

PY - 2019/5

Y1 - 2019/5

N2 - OBJECTIVE: To describe the cross-sectional and longitudinal associations between quantitative measures of infrapatellar fat pad (IPFP) signal intensity alteration and knee structural abnormalities in patients with symptomatic knee OA.METHODS: 261 participants (mean age 63.0 ± 7.2 years) with symptomatic knee OA were selected from a randomized controlled trial with a follow up of 2 years. IPFP signal intensity alterations at baseline were quantitatively measured on T2-weighted fat-saturated MRI using MATLAB. These quantitative measures included the standard deviation [sDev (IPFP)] of whole IPFP signal intensity, the upper quartile value [UQ (H)] of high signal intensity, the ratio of volume of high signal intensity alteration to volume of whole IPFP [Percentage (H)] and Clustering factor (H) representing the clustering effect of high signal intensity. Cartilage volume and defects, and BMLs were assessed using validated measures RESULTS: Higher baseline sDev (IPFP), UQ (H) and Clustering factor (H) were associated with greater loss of tibial cartilage volume and larger increases in tibiofemoral cartilage defects over 2 years. Patients with high and medium tertiles of Clustering factor (H) had greater loss of cartilage volume per annum compared with those with low tertile (4.9% and 4.6% vs 3.3% p.a.). Baseline Percentage (H) and Clustering factor (H) were positively and significantly associated with increases in tibiofemoral BMLs over 2 years. Cross-sectional associations between IPFP measures and knee structures were similar but more consistent.CONCLUSION: Quantitative measures of increased signal intensity in the IPFP were associated with knee structural abnormalities in tibiofemoral compartment, suggesting that these measurements could be used as an additional entry criteria in order to enrich for 'faster progressors' in studies of knee OA.

AB - OBJECTIVE: To describe the cross-sectional and longitudinal associations between quantitative measures of infrapatellar fat pad (IPFP) signal intensity alteration and knee structural abnormalities in patients with symptomatic knee OA.METHODS: 261 participants (mean age 63.0 ± 7.2 years) with symptomatic knee OA were selected from a randomized controlled trial with a follow up of 2 years. IPFP signal intensity alterations at baseline were quantitatively measured on T2-weighted fat-saturated MRI using MATLAB. These quantitative measures included the standard deviation [sDev (IPFP)] of whole IPFP signal intensity, the upper quartile value [UQ (H)] of high signal intensity, the ratio of volume of high signal intensity alteration to volume of whole IPFP [Percentage (H)] and Clustering factor (H) representing the clustering effect of high signal intensity. Cartilage volume and defects, and BMLs were assessed using validated measures RESULTS: Higher baseline sDev (IPFP), UQ (H) and Clustering factor (H) were associated with greater loss of tibial cartilage volume and larger increases in tibiofemoral cartilage defects over 2 years. Patients with high and medium tertiles of Clustering factor (H) had greater loss of cartilage volume per annum compared with those with low tertile (4.9% and 4.6% vs 3.3% p.a.). Baseline Percentage (H) and Clustering factor (H) were positively and significantly associated with increases in tibiofemoral BMLs over 2 years. Cross-sectional associations between IPFP measures and knee structures were similar but more consistent.CONCLUSION: Quantitative measures of increased signal intensity in the IPFP were associated with knee structural abnormalities in tibiofemoral compartment, suggesting that these measurements could be used as an additional entry criteria in order to enrich for 'faster progressors' in studies of knee OA.

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DO - 10.1002/acr.23713

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