Association Between Obesity and Wound Infection Following Colorectal Surgery: Systematic Review and Meta-Analysis

Usha Gurunathan, Simone Ramsay, Goran Mitrić, Mandy Way, Leesa Wockner, Paul Myles

Research output: Contribution to journalReview ArticleResearchpeer-review

Abstract

Background: The aim of this meta-analysis is to comprehensively review and quantify the excess risk of surgical site infections (SSI) in obese patients following colorectal surgery. Methods: A systematic electronic search of the MEDLINE and EMBASE databases identified studies that investigated the association of obesity, defined by body mass index (BMI) with SSI among colorectal surgery patients. Results: Twelve studies were included in the final analysis. Patients with BMI ≥30 kg/m2 were at 1.5 times (pooled OR 1.51, 95% CI: 1.39, 1.63, p < 0.001) higher odds of developing SSI after colorectal surgery when compared to BMI <30 kg/m2. Subgroup analysis of the eight studies that investigated only elective procedures showed that the odds of developing SSI when BMI ≥30 kg/m2 is 1.6 times that of those with BMI <30 kg/m2 (pooled OR 1.60; 95% CI 1.34, 1.86; p < 0.001). The odds of having SSI when BMI is 25–29.9 kg/m2 are 1.2 times than those with BMI <25 kg/m2 (pooled OR 1.17; 95% CI 1.07, 1.28; p < 0.001). Conclusion: Overweight and obese patients carry at least 20% and 50% higher odds of developing SSI after colorectal surgery compared to normal weight patients, respectively.

Original languageEnglish
Pages (from-to)1700-1712
Number of pages13
JournalJournal of Gastrointestinal Surgery
Volume21
Issue number10
DOIs
Publication statusPublished - 1 Oct 2017

Keywords

  • Colorectal surgery
  • Obesity
  • Surgical site infection

Cite this

Gurunathan, Usha ; Ramsay, Simone ; Mitrić, Goran ; Way, Mandy ; Wockner, Leesa ; Myles, Paul. / Association Between Obesity and Wound Infection Following Colorectal Surgery : Systematic Review and Meta-Analysis. In: Journal of Gastrointestinal Surgery. 2017 ; Vol. 21, No. 10. pp. 1700-1712.
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abstract = "Background: The aim of this meta-analysis is to comprehensively review and quantify the excess risk of surgical site infections (SSI) in obese patients following colorectal surgery. Methods: A systematic electronic search of the MEDLINE and EMBASE databases identified studies that investigated the association of obesity, defined by body mass index (BMI) with SSI among colorectal surgery patients. Results: Twelve studies were included in the final analysis. Patients with BMI ≥30 kg/m2 were at 1.5 times (pooled OR 1.51, 95{\%} CI: 1.39, 1.63, p < 0.001) higher odds of developing SSI after colorectal surgery when compared to BMI <30 kg/m2. Subgroup analysis of the eight studies that investigated only elective procedures showed that the odds of developing SSI when BMI ≥30 kg/m2 is 1.6 times that of those with BMI <30 kg/m2 (pooled OR 1.60; 95{\%} CI 1.34, 1.86; p < 0.001). The odds of having SSI when BMI is 25–29.9 kg/m2 are 1.2 times than those with BMI <25 kg/m2 (pooled OR 1.17; 95{\%} CI 1.07, 1.28; p < 0.001). Conclusion: Overweight and obese patients carry at least 20{\%} and 50{\%} higher odds of developing SSI after colorectal surgery compared to normal weight patients, respectively.",
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Association Between Obesity and Wound Infection Following Colorectal Surgery : Systematic Review and Meta-Analysis. / Gurunathan, Usha; Ramsay, Simone; Mitrić, Goran; Way, Mandy; Wockner, Leesa; Myles, Paul.

In: Journal of Gastrointestinal Surgery, Vol. 21, No. 10, 01.10.2017, p. 1700-1712.

Research output: Contribution to journalReview ArticleResearchpeer-review

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T1 - Association Between Obesity and Wound Infection Following Colorectal Surgery

T2 - Systematic Review and Meta-Analysis

AU - Gurunathan, Usha

AU - Ramsay, Simone

AU - Mitrić, Goran

AU - Way, Mandy

AU - Wockner, Leesa

AU - Myles, Paul

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Y1 - 2017/10/1

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KW - Obesity

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