Association between MRI-detected osteophytes and changes in knee structures and pain in older adults: a cohort study

Z. Zhu, Laura Louise Laslett, X. Jin, W. Han, Benny Eathakkattu Antony, X. Wang, M. Lu, F. Cicuttini, G. Jones, C. Ding

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Objective To describe cross-sectional and longitudinal associations between magnetic resonance imaging (MRI)-detected osteophytes (OPs) and knee structural abnormalities and knee pain in older adults. Method A prospective population-based cohort study of 895 participants aged 50–80 years (mean age 62 years, 50% female) was performed. T1-or T2-weighted fat suppressed MRI was used to assess knee OPs, cartilage volume, cartilage defects and bone marrow lesions (BMLs) at baseline and after 2.6 years. Radiographically-detected OPs were scored according to the Osteoarthritis Research Society International (OARSI) atlas. Knee pain was assessed using a self-administered questionnaire at baseline, 2.6 and 5 years later. Results 85% of participants had MRI-detected OPs at baseline, while 10% of participants had radiographically-detected OPs. Cross-sectionally, higher gardes of MRI-detected OPs in all compartments were significantly, independently and site-specifically associated with higher prevalences of cartilage defects and BMLs, lower cartilage volume and higher prevalence of knee pain. Longitudinally, higher gardes of baseline MRI-detected OPs site-specifically predicted greater risks of any increase in cartilage defects or BMLs, and loss of cartilage volume in medial and lateral tibiofemoral (LTF) and total compartments over 2.6 years in multivariable analyses. These significant associations were similar in those without radiographically-detected OPs. MTF and total OP scores were significantly associated with change in total knee pain over 2.6 and 5 years but these became non-significant after adjustment for cartilage defects and BMLs. Conclusion MRI-detected knee OPs are common and appear to be clinically relevant to knee structural changes in older adults.

Original languageEnglish
Pages (from-to)1084-1092
Number of pages9
JournalOsteoarthritis and Cartilage
Volume25
Issue number7
DOIs
Publication statusPublished - 1 Jul 2017

Keywords

  • Knee osteoarthritis
  • Knee pain
  • Knee structures abnormalities
  • Magnetic resonance imaging
  • Osteophytes

Cite this

Zhu, Z. ; Laslett, Laura Louise ; Jin, X. ; Han, W. ; Antony, Benny Eathakkattu ; Wang, X. ; Lu, M. ; Cicuttini, F. ; Jones, G. ; Ding, C. / Association between MRI-detected osteophytes and changes in knee structures and pain in older adults : a cohort study. In: Osteoarthritis and Cartilage. 2017 ; Vol. 25, No. 7. pp. 1084-1092.
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title = "Association between MRI-detected osteophytes and changes in knee structures and pain in older adults: a cohort study",
abstract = "Objective To describe cross-sectional and longitudinal associations between magnetic resonance imaging (MRI)-detected osteophytes (OPs) and knee structural abnormalities and knee pain in older adults. Method A prospective population-based cohort study of 895 participants aged 50–80 years (mean age 62 years, 50{\%} female) was performed. T1-or T2-weighted fat suppressed MRI was used to assess knee OPs, cartilage volume, cartilage defects and bone marrow lesions (BMLs) at baseline and after 2.6 years. Radiographically-detected OPs were scored according to the Osteoarthritis Research Society International (OARSI) atlas. Knee pain was assessed using a self-administered questionnaire at baseline, 2.6 and 5 years later. Results 85{\%} of participants had MRI-detected OPs at baseline, while 10{\%} of participants had radiographically-detected OPs. Cross-sectionally, higher gardes of MRI-detected OPs in all compartments were significantly, independently and site-specifically associated with higher prevalences of cartilage defects and BMLs, lower cartilage volume and higher prevalence of knee pain. Longitudinally, higher gardes of baseline MRI-detected OPs site-specifically predicted greater risks of any increase in cartilage defects or BMLs, and loss of cartilage volume in medial and lateral tibiofemoral (LTF) and total compartments over 2.6 years in multivariable analyses. These significant associations were similar in those without radiographically-detected OPs. MTF and total OP scores were significantly associated with change in total knee pain over 2.6 and 5 years but these became non-significant after adjustment for cartilage defects and BMLs. Conclusion MRI-detected knee OPs are common and appear to be clinically relevant to knee structural changes in older adults.",
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author = "Z. Zhu and Laslett, {Laura Louise} and X. Jin and W. Han and Antony, {Benny Eathakkattu} and X. Wang and M. Lu and F. Cicuttini and G. Jones and C. Ding",
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Association between MRI-detected osteophytes and changes in knee structures and pain in older adults : a cohort study. / Zhu, Z.; Laslett, Laura Louise; Jin, X.; Han, W.; Antony, Benny Eathakkattu; Wang, X.; Lu, M.; Cicuttini, F.; Jones, G.; Ding, C.

In: Osteoarthritis and Cartilage, Vol. 25, No. 7, 01.07.2017, p. 1084-1092.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Association between MRI-detected osteophytes and changes in knee structures and pain in older adults

T2 - a cohort study

AU - Zhu, Z.

AU - Laslett, Laura Louise

AU - Jin, X.

AU - Han, W.

AU - Antony, Benny Eathakkattu

AU - Wang, X.

AU - Lu, M.

AU - Cicuttini, F.

AU - Jones, G.

AU - Ding, C.

PY - 2017/7/1

Y1 - 2017/7/1

N2 - Objective To describe cross-sectional and longitudinal associations between magnetic resonance imaging (MRI)-detected osteophytes (OPs) and knee structural abnormalities and knee pain in older adults. Method A prospective population-based cohort study of 895 participants aged 50–80 years (mean age 62 years, 50% female) was performed. T1-or T2-weighted fat suppressed MRI was used to assess knee OPs, cartilage volume, cartilage defects and bone marrow lesions (BMLs) at baseline and after 2.6 years. Radiographically-detected OPs were scored according to the Osteoarthritis Research Society International (OARSI) atlas. Knee pain was assessed using a self-administered questionnaire at baseline, 2.6 and 5 years later. Results 85% of participants had MRI-detected OPs at baseline, while 10% of participants had radiographically-detected OPs. Cross-sectionally, higher gardes of MRI-detected OPs in all compartments were significantly, independently and site-specifically associated with higher prevalences of cartilage defects and BMLs, lower cartilage volume and higher prevalence of knee pain. Longitudinally, higher gardes of baseline MRI-detected OPs site-specifically predicted greater risks of any increase in cartilage defects or BMLs, and loss of cartilage volume in medial and lateral tibiofemoral (LTF) and total compartments over 2.6 years in multivariable analyses. These significant associations were similar in those without radiographically-detected OPs. MTF and total OP scores were significantly associated with change in total knee pain over 2.6 and 5 years but these became non-significant after adjustment for cartilage defects and BMLs. Conclusion MRI-detected knee OPs are common and appear to be clinically relevant to knee structural changes in older adults.

AB - Objective To describe cross-sectional and longitudinal associations between magnetic resonance imaging (MRI)-detected osteophytes (OPs) and knee structural abnormalities and knee pain in older adults. Method A prospective population-based cohort study of 895 participants aged 50–80 years (mean age 62 years, 50% female) was performed. T1-or T2-weighted fat suppressed MRI was used to assess knee OPs, cartilage volume, cartilage defects and bone marrow lesions (BMLs) at baseline and after 2.6 years. Radiographically-detected OPs were scored according to the Osteoarthritis Research Society International (OARSI) atlas. Knee pain was assessed using a self-administered questionnaire at baseline, 2.6 and 5 years later. Results 85% of participants had MRI-detected OPs at baseline, while 10% of participants had radiographically-detected OPs. Cross-sectionally, higher gardes of MRI-detected OPs in all compartments were significantly, independently and site-specifically associated with higher prevalences of cartilage defects and BMLs, lower cartilage volume and higher prevalence of knee pain. Longitudinally, higher gardes of baseline MRI-detected OPs site-specifically predicted greater risks of any increase in cartilage defects or BMLs, and loss of cartilage volume in medial and lateral tibiofemoral (LTF) and total compartments over 2.6 years in multivariable analyses. These significant associations were similar in those without radiographically-detected OPs. MTF and total OP scores were significantly associated with change in total knee pain over 2.6 and 5 years but these became non-significant after adjustment for cartilage defects and BMLs. Conclusion MRI-detected knee OPs are common and appear to be clinically relevant to knee structural changes in older adults.

KW - Knee osteoarthritis

KW - Knee pain

KW - Knee structures abnormalities

KW - Magnetic resonance imaging

KW - Osteophytes

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U2 - 10.1016/j.joca.2017.01.007

DO - 10.1016/j.joca.2017.01.007

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JO - Osteoarthritis and Cartilage

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SN - 1063-4584

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