Association between moderate and late preterm birth and neurodevelopment and social-emotional development at age 2 years

Jeanie L. Cheong, Lex W. Doyle, Alice C. Burnett, Katherine J Lee, Jennifer M. Walsh, Cody R. Potter, Karli Treyvaud, Deanne K Thompson, Joy E. Olsen, Peter J. Anderson, Alicia Jane Spittle

Research output: Contribution to journalArticleResearchpeer-review

Abstract

IMPORTANCE Moderate and late preterm (MLPT) births comprise most preterm infants. Therefore, long-term developmental concerns in this population potentially have a large public health influence. While there are increasing reports of developmental problems in MLPT children, detail is lacking on the precise domains that are affected. OBJECTIVE To compare neurodevelopment and social-emotional development between MLPT infants and term-born control infants at age 2 years. DESIGN, SETTING, AND PARTICIPANTS This investigationwas a prospective longitudinal cohort study at a single tertiary hospital. Participants were MLPT infants (32-36 weeks' completed gestation) and healthy full-term controls (≥37 weeks' gestation) recruited at birth. During a 3-year period between December 7, 2009, and November 7, 2012, MLPT infants were recruited at birth from the neonatal unit and postnatal wards of the Royal Women's Hospital, Melbourne, Australia. The term control recruitment extended to March 26, 2014. The dates of the data developmental assessments were February 23, 2012, to April 8, 2016. EXPOSURE Moderate and late preterm birth. MAIN OUTCOMES AND MEASURES Cerebral palsy, blindness, and deafness assessed by a pediatrician; cognitive, language, and motor development assessed using the Bayley Scales of Infant Development-Third Edition (developmental delay was defined as less than -1 SD relative to the mean in controls in any domain of the scales); and social-emotional and behavioral problems assessed by a parent questionnaire (Infant Toddler Social Emotional Assessment). Outcomes were compared between birth groups using linear and logistic regression, adjusted for social risk. RESULTS In total, 198 MLPT infants (98.5%of 201 recruited) and 183 term-born controls (91.0% of 201 recruited) were assessed at 2 years' corrected age. Compared with controls, MLPT children had worse cognitive, language, and motor development at age 2 years, with adjusted composite score mean differences of -5.3 (95%CI, -8.2 to -2.4) for cognitive development, -11.4 (95%CI, -15.3 to -7.5) for language development, and -7.3 (95%CI, -10.6 to -3.9) for motor development. The odds of developmental delay were higher in the MLPT group compared with controls, with adjusted odds ratios of 1.8 (95%CI, 1.1-3.0) for cognitive delay, 3.1 (95%CI, 1.8-5.2) for language delay, and 2.4 (95%CI, 1.3-4.5) for motor delay. Overall social-emotional competence was worse in MLPT children compared with controls (t statistic mean difference, -3.6 (95%CI, -5.8 to -1.4), but other behavioral domains were similar. The odds of being at risk for social-emotional competence were 3.9 (95%CI, 1.4-10.9) for MLPT children compared with controls. CONCLUSIONS AND RELEVANCE Moderate and late preterm children exhibited developmental delay compared with their term-born peers, most marked in the language domain. This knowledge of developmental needs in MLPT infants will assist in targeting surveillance and intervention.

Original languageEnglish
Number of pages7
JournalJAMA Pediatrics
Volume171
Issue number4
DOIs
Publication statusPublished - 1 Apr 2017
Externally publishedYes

Cite this

Cheong, J. L., Doyle, L. W., Burnett, A. C., Lee, K. J., Walsh, J. M., Potter, C. R., ... Spittle, A. J. (2017). Association between moderate and late preterm birth and neurodevelopment and social-emotional development at age 2 years. JAMA Pediatrics, 171(4). https://doi.org/10.1001/jamapediatrics.2016.4805
Cheong, Jeanie L. ; Doyle, Lex W. ; Burnett, Alice C. ; Lee, Katherine J ; Walsh, Jennifer M. ; Potter, Cody R. ; Treyvaud, Karli ; Thompson, Deanne K ; Olsen, Joy E. ; Anderson, Peter J. ; Spittle, Alicia Jane. / Association between moderate and late preterm birth and neurodevelopment and social-emotional development at age 2 years. In: JAMA Pediatrics. 2017 ; Vol. 171, No. 4.
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abstract = "IMPORTANCE Moderate and late preterm (MLPT) births comprise most preterm infants. Therefore, long-term developmental concerns in this population potentially have a large public health influence. While there are increasing reports of developmental problems in MLPT children, detail is lacking on the precise domains that are affected. OBJECTIVE To compare neurodevelopment and social-emotional development between MLPT infants and term-born control infants at age 2 years. DESIGN, SETTING, AND PARTICIPANTS This investigationwas a prospective longitudinal cohort study at a single tertiary hospital. Participants were MLPT infants (32-36 weeks' completed gestation) and healthy full-term controls (≥37 weeks' gestation) recruited at birth. During a 3-year period between December 7, 2009, and November 7, 2012, MLPT infants were recruited at birth from the neonatal unit and postnatal wards of the Royal Women's Hospital, Melbourne, Australia. The term control recruitment extended to March 26, 2014. The dates of the data developmental assessments were February 23, 2012, to April 8, 2016. EXPOSURE Moderate and late preterm birth. MAIN OUTCOMES AND MEASURES Cerebral palsy, blindness, and deafness assessed by a pediatrician; cognitive, language, and motor development assessed using the Bayley Scales of Infant Development-Third Edition (developmental delay was defined as less than -1 SD relative to the mean in controls in any domain of the scales); and social-emotional and behavioral problems assessed by a parent questionnaire (Infant Toddler Social Emotional Assessment). Outcomes were compared between birth groups using linear and logistic regression, adjusted for social risk. RESULTS In total, 198 MLPT infants (98.5{\%}of 201 recruited) and 183 term-born controls (91.0{\%} of 201 recruited) were assessed at 2 years' corrected age. Compared with controls, MLPT children had worse cognitive, language, and motor development at age 2 years, with adjusted composite score mean differences of -5.3 (95{\%}CI, -8.2 to -2.4) for cognitive development, -11.4 (95{\%}CI, -15.3 to -7.5) for language development, and -7.3 (95{\%}CI, -10.6 to -3.9) for motor development. The odds of developmental delay were higher in the MLPT group compared with controls, with adjusted odds ratios of 1.8 (95{\%}CI, 1.1-3.0) for cognitive delay, 3.1 (95{\%}CI, 1.8-5.2) for language delay, and 2.4 (95{\%}CI, 1.3-4.5) for motor delay. Overall social-emotional competence was worse in MLPT children compared with controls (t statistic mean difference, -3.6 (95{\%}CI, -5.8 to -1.4), but other behavioral domains were similar. The odds of being at risk for social-emotional competence were 3.9 (95{\%}CI, 1.4-10.9) for MLPT children compared with controls. CONCLUSIONS AND RELEVANCE Moderate and late preterm children exhibited developmental delay compared with their term-born peers, most marked in the language domain. This knowledge of developmental needs in MLPT infants will assist in targeting surveillance and intervention.",
author = "Cheong, {Jeanie L.} and Doyle, {Lex W.} and Burnett, {Alice C.} and Lee, {Katherine J} and Walsh, {Jennifer M.} and Potter, {Cody R.} and Karli Treyvaud and Thompson, {Deanne K} and Olsen, {Joy E.} and Anderson, {Peter J.} and Spittle, {Alicia Jane}",
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Cheong, JL, Doyle, LW, Burnett, AC, Lee, KJ, Walsh, JM, Potter, CR, Treyvaud, K, Thompson, DK, Olsen, JE, Anderson, PJ & Spittle, AJ 2017, 'Association between moderate and late preterm birth and neurodevelopment and social-emotional development at age 2 years' JAMA Pediatrics, vol. 171, no. 4. https://doi.org/10.1001/jamapediatrics.2016.4805

Association between moderate and late preterm birth and neurodevelopment and social-emotional development at age 2 years. / Cheong, Jeanie L.; Doyle, Lex W.; Burnett, Alice C.; Lee, Katherine J; Walsh, Jennifer M.; Potter, Cody R.; Treyvaud, Karli; Thompson, Deanne K; Olsen, Joy E.; Anderson, Peter J.; Spittle, Alicia Jane.

In: JAMA Pediatrics, Vol. 171, No. 4, 01.04.2017.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Association between moderate and late preterm birth and neurodevelopment and social-emotional development at age 2 years

AU - Cheong, Jeanie L.

AU - Doyle, Lex W.

AU - Burnett, Alice C.

AU - Lee, Katherine J

AU - Walsh, Jennifer M.

AU - Potter, Cody R.

AU - Treyvaud, Karli

AU - Thompson, Deanne K

AU - Olsen, Joy E.

AU - Anderson, Peter J.

AU - Spittle, Alicia Jane

PY - 2017/4/1

Y1 - 2017/4/1

N2 - IMPORTANCE Moderate and late preterm (MLPT) births comprise most preterm infants. Therefore, long-term developmental concerns in this population potentially have a large public health influence. While there are increasing reports of developmental problems in MLPT children, detail is lacking on the precise domains that are affected. OBJECTIVE To compare neurodevelopment and social-emotional development between MLPT infants and term-born control infants at age 2 years. DESIGN, SETTING, AND PARTICIPANTS This investigationwas a prospective longitudinal cohort study at a single tertiary hospital. Participants were MLPT infants (32-36 weeks' completed gestation) and healthy full-term controls (≥37 weeks' gestation) recruited at birth. During a 3-year period between December 7, 2009, and November 7, 2012, MLPT infants were recruited at birth from the neonatal unit and postnatal wards of the Royal Women's Hospital, Melbourne, Australia. The term control recruitment extended to March 26, 2014. The dates of the data developmental assessments were February 23, 2012, to April 8, 2016. EXPOSURE Moderate and late preterm birth. MAIN OUTCOMES AND MEASURES Cerebral palsy, blindness, and deafness assessed by a pediatrician; cognitive, language, and motor development assessed using the Bayley Scales of Infant Development-Third Edition (developmental delay was defined as less than -1 SD relative to the mean in controls in any domain of the scales); and social-emotional and behavioral problems assessed by a parent questionnaire (Infant Toddler Social Emotional Assessment). Outcomes were compared between birth groups using linear and logistic regression, adjusted for social risk. RESULTS In total, 198 MLPT infants (98.5%of 201 recruited) and 183 term-born controls (91.0% of 201 recruited) were assessed at 2 years' corrected age. Compared with controls, MLPT children had worse cognitive, language, and motor development at age 2 years, with adjusted composite score mean differences of -5.3 (95%CI, -8.2 to -2.4) for cognitive development, -11.4 (95%CI, -15.3 to -7.5) for language development, and -7.3 (95%CI, -10.6 to -3.9) for motor development. The odds of developmental delay were higher in the MLPT group compared with controls, with adjusted odds ratios of 1.8 (95%CI, 1.1-3.0) for cognitive delay, 3.1 (95%CI, 1.8-5.2) for language delay, and 2.4 (95%CI, 1.3-4.5) for motor delay. Overall social-emotional competence was worse in MLPT children compared with controls (t statistic mean difference, -3.6 (95%CI, -5.8 to -1.4), but other behavioral domains were similar. The odds of being at risk for social-emotional competence were 3.9 (95%CI, 1.4-10.9) for MLPT children compared with controls. CONCLUSIONS AND RELEVANCE Moderate and late preterm children exhibited developmental delay compared with their term-born peers, most marked in the language domain. This knowledge of developmental needs in MLPT infants will assist in targeting surveillance and intervention.

AB - IMPORTANCE Moderate and late preterm (MLPT) births comprise most preterm infants. Therefore, long-term developmental concerns in this population potentially have a large public health influence. While there are increasing reports of developmental problems in MLPT children, detail is lacking on the precise domains that are affected. OBJECTIVE To compare neurodevelopment and social-emotional development between MLPT infants and term-born control infants at age 2 years. DESIGN, SETTING, AND PARTICIPANTS This investigationwas a prospective longitudinal cohort study at a single tertiary hospital. Participants were MLPT infants (32-36 weeks' completed gestation) and healthy full-term controls (≥37 weeks' gestation) recruited at birth. During a 3-year period between December 7, 2009, and November 7, 2012, MLPT infants were recruited at birth from the neonatal unit and postnatal wards of the Royal Women's Hospital, Melbourne, Australia. The term control recruitment extended to March 26, 2014. The dates of the data developmental assessments were February 23, 2012, to April 8, 2016. EXPOSURE Moderate and late preterm birth. MAIN OUTCOMES AND MEASURES Cerebral palsy, blindness, and deafness assessed by a pediatrician; cognitive, language, and motor development assessed using the Bayley Scales of Infant Development-Third Edition (developmental delay was defined as less than -1 SD relative to the mean in controls in any domain of the scales); and social-emotional and behavioral problems assessed by a parent questionnaire (Infant Toddler Social Emotional Assessment). Outcomes were compared between birth groups using linear and logistic regression, adjusted for social risk. RESULTS In total, 198 MLPT infants (98.5%of 201 recruited) and 183 term-born controls (91.0% of 201 recruited) were assessed at 2 years' corrected age. Compared with controls, MLPT children had worse cognitive, language, and motor development at age 2 years, with adjusted composite score mean differences of -5.3 (95%CI, -8.2 to -2.4) for cognitive development, -11.4 (95%CI, -15.3 to -7.5) for language development, and -7.3 (95%CI, -10.6 to -3.9) for motor development. The odds of developmental delay were higher in the MLPT group compared with controls, with adjusted odds ratios of 1.8 (95%CI, 1.1-3.0) for cognitive delay, 3.1 (95%CI, 1.8-5.2) for language delay, and 2.4 (95%CI, 1.3-4.5) for motor delay. Overall social-emotional competence was worse in MLPT children compared with controls (t statistic mean difference, -3.6 (95%CI, -5.8 to -1.4), but other behavioral domains were similar. The odds of being at risk for social-emotional competence were 3.9 (95%CI, 1.4-10.9) for MLPT children compared with controls. CONCLUSIONS AND RELEVANCE Moderate and late preterm children exhibited developmental delay compared with their term-born peers, most marked in the language domain. This knowledge of developmental needs in MLPT infants will assist in targeting surveillance and intervention.

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