TY - JOUR
T1 - Association between mercury exposure and lung function in young adults
T2 - A prospective cohort study in Shandong, China
AU - Miao, Jiaming
AU - Feng, Shurong
AU - Dou, Siqi
AU - Ma, Yang
AU - Yang, Liu
AU - Yan, Lailai
AU - Yu, Pei
AU - Wu, Yao
AU - Ye, Tingting
AU - Wen, Bo
AU - Lu, Peng
AU - Li, Shanshan
AU - Guo, Yuming
N1 - Funding Information:
The study was supported by Taishan Scholar Program . PL was sponsored by Taishan Scholar Foundation ( tsqn202211228 ), Shandong Province Natural Science Foundation ( ZR202103050697 ) and Shandong Province Environmental Health Innovative Team . YG was supported by Career Development Fellowship ( GNT1163693 ) and Leader Fellowship ( GNT2008813 ) of the Australian National Health and Medical Research Council . SL was supported by an Emerging Leader Fellowship of the Australian National Health and Medical Research Council ( GNT2009866 )
Publisher Copyright:
© 2023 Elsevier B.V.
PY - 2023/6/20
Y1 - 2023/6/20
N2 - Background: Mercury has been associated with many adverse health outcomes. However, limited studies have explored the association between blood mercury concentrations and lung function. Objective: To examine the association between blood mercury concentrations and lung function among young adults. Methods: We conducted a prospective cohort study among 1800 college students based on the Chinese Undergraduates Cohort in Shandong, China during August 2019 and September 2020. Lung function indicators including forced vital capacity (FVC, ml), forced expiratory volume in 1 s (FEV1, ml) and peak expiratory flow (PEF, ml) were collected with a spirometers (Chestgraph Jr. HI-101, Chest M.I., Tokyo, Japan). The blood mercury concentration was measured using inductively coupled plasma mass spectrometry. We divided participants into low (≤25 percentiles), intermediate (25–75 percentiles), and high (≥75 percentile) subgroups according to blood mercury concentrations. The multiple linear regression model was used to examine the associations between blood mercury concentrations and lung function changes. Stratification analyses by sex and fish consumption frequency were also conducted. Results: The results showed that each 2-fold increase in blood mercury concentrations was significantly associated with −70.75 ml [95 % confidence interval (CI): −122.35, −19.15] change in FVC, −72.68 ml (95%CI: −120.36, −25.00) in FEV1, and −158.06 ml (95%CI: −283.77, −32.35) in PEF. The effect was more pronounced among participants with high blood mercury and male participants. Participants who consumed fish more than once a week more likely to be affected by mercury. Conclusion: Our study indicated that blood mercury was significantly associated with decreased lung function in young adults. It is necessary to implement corresponding measures to reduce the effect of mercury on the respiratory system, especially for men and people who consumed fish more than once a week.
AB - Background: Mercury has been associated with many adverse health outcomes. However, limited studies have explored the association between blood mercury concentrations and lung function. Objective: To examine the association between blood mercury concentrations and lung function among young adults. Methods: We conducted a prospective cohort study among 1800 college students based on the Chinese Undergraduates Cohort in Shandong, China during August 2019 and September 2020. Lung function indicators including forced vital capacity (FVC, ml), forced expiratory volume in 1 s (FEV1, ml) and peak expiratory flow (PEF, ml) were collected with a spirometers (Chestgraph Jr. HI-101, Chest M.I., Tokyo, Japan). The blood mercury concentration was measured using inductively coupled plasma mass spectrometry. We divided participants into low (≤25 percentiles), intermediate (25–75 percentiles), and high (≥75 percentile) subgroups according to blood mercury concentrations. The multiple linear regression model was used to examine the associations between blood mercury concentrations and lung function changes. Stratification analyses by sex and fish consumption frequency were also conducted. Results: The results showed that each 2-fold increase in blood mercury concentrations was significantly associated with −70.75 ml [95 % confidence interval (CI): −122.35, −19.15] change in FVC, −72.68 ml (95%CI: −120.36, −25.00) in FEV1, and −158.06 ml (95%CI: −283.77, −32.35) in PEF. The effect was more pronounced among participants with high blood mercury and male participants. Participants who consumed fish more than once a week more likely to be affected by mercury. Conclusion: Our study indicated that blood mercury was significantly associated with decreased lung function in young adults. It is necessary to implement corresponding measures to reduce the effect of mercury on the respiratory system, especially for men and people who consumed fish more than once a week.
KW - Lung function impairment
KW - Mercury
KW - Prospective cohort study
KW - Young adult
UR - http://www.scopus.com/inward/record.url?scp=85150484833&partnerID=8YFLogxK
U2 - 10.1016/j.scitotenv.2023.162759
DO - 10.1016/j.scitotenv.2023.162759
M3 - Article
C2 - 36907407
AN - SCOPUS:85150484833
SN - 0048-9697
VL - 878
JO - Science of the Total Environment
JF - Science of the Total Environment
M1 - 162759
ER -