Association between long-term exposure to wildfire-related PM_2.5 and mortality: A longitudinal analysis of the UK Biobank

Little is known about the associations between long-term exposure to wildfire-related fine particulate matter (PM_2.5) and mortality. We aimed to explore theses associations using the data from the UK Biobank cohort. Long-term wildfire-related PM_2.5 exposure was defined as the 3-year cumulative concentrations of wildfire-related PM_2.5 within a 10-km buffer surrounding the residential address for each individual. Hazard ratios (HRs) with 95% confidence intervals (CIs) were estimated using the time-varying Cox regression model. We included 492,394 participants aged between 38 and 73 years. We found that after adjusting for potential covariates, a 10 μg/m³ increase of wildfire-related PM_2.5 exposure was associated with a 0.4% higher risk of all-cause mortality (HR = 1.004 [95% CI: 1.001, 1.006]) and nonaccidental mortality (HR = 1.004 [95% CI: 1.002, 1.006]), and a 0.5% higher risk of neoplasm mortality (HR = 1.005 [95% CI: 1.002, 1.008]). However, no significant associations were observed between wildfire-related PM_2.5 exposure and mortality from cardiovascular, respiratory, and mental diseases. Additionally, no significant modification effects of a series of modifiers were observed. Targeted health protection strategies should be adopted in response to wildfire-related PM_2.5 exposure, in order to reduce the risk of premature mortality.