TY - JOUR
T1 - Association Between Collagenous and Lymphocytic Colitis and Risk of Severe Coronavirus Disease 2019
AU - Khalili, Hamed
AU - Zheng, Tenghao
AU - Söderling, Jonas
AU - Larsson, Emma
AU - on behalf of COVID19 and microscopic colitis collaborators
AU - D'Amato, Mauro
AU - Ludvigsson, Jonas F.
N1 - Funding Information:
Funding This study was funded by Karolinska Institutet . Jonas F. Ludvigsson and Hamed Khalili receive National Institutes of Health funding from the National Institute of Aging (R01 AG068390) to study the relation ut microbiome, and microscopic colitis.
Funding Information:
Conflicts of interest These authors disclose the following: Hamed Khalili has received consulting fees from Takeda and research funding from Takeda and Pfizer. Jonas F. Ludvigsson coordinates a study on behalf of the Swedish IBD quality register (SWIBREG) that has received funding from Janssen Corporation. Jonas F. Ludvigsson and Hamed Khalili receive National Institutes of Health funding from the National Institute of Aging (R01 AG068390) to study the relationship between medications, the gut microbiome, and microscopic colitis.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/6
Y1 - 2021/6
N2 - Microscopic colitis (MC) is a chronic inflammatory disease of the large intestine that presents with watery diarrhea and primarily affects older adults. We and others have demonstrated that MC is associated with an increased risk of death from infectious causes. 1 ,2 Severe acute respiratory syndrome coronavirus 2 is a novel virus first discovered in China and is responsible for coronavirus disease 2019 (COVID-19). To date, no study has evaluated the association between MC, its subtypes of collagenous colitis (CC) and lymphocytic colitis (LC), and COVID-19. We therefore sought to examine the risk of severe COVID-19 in patients with MC as compared with the general population. We also compared the frequency of a risk variant from the 3p21.31 gene cluster associated with severe COVID-19 3 across MC subtypes.
AB - Microscopic colitis (MC) is a chronic inflammatory disease of the large intestine that presents with watery diarrhea and primarily affects older adults. We and others have demonstrated that MC is associated with an increased risk of death from infectious causes. 1 ,2 Severe acute respiratory syndrome coronavirus 2 is a novel virus first discovered in China and is responsible for coronavirus disease 2019 (COVID-19). To date, no study has evaluated the association between MC, its subtypes of collagenous colitis (CC) and lymphocytic colitis (LC), and COVID-19. We therefore sought to examine the risk of severe COVID-19 in patients with MC as compared with the general population. We also compared the frequency of a risk variant from the 3p21.31 gene cluster associated with severe COVID-19 3 across MC subtypes.
UR - https://www.scopus.com/pages/publications/85106511809
U2 - 10.1053/j.gastro.2021.02.029
DO - 10.1053/j.gastro.2021.02.029
M3 - Short Survey
C2 - 33610527
AN - SCOPUS:85106511809
SN - 0016-5085
VL - 160
SP - 2585-2587.e3
JO - Gastroenterology
JF - Gastroenterology
IS - 7
ER -
SDG 3 Good Health and Well-being