Microscopic colitis (MC) is a chronic inflammatory disease of the large intestine that presents with watery diarrhea and primarily affects older adults. We and others have demonstrated that MC is associated with an increased risk of death from infectious causes. 1 ,2 Severe acute respiratory syndrome coronavirus 2 is a novel virus first discovered in China and is responsible for coronavirus disease 2019 (COVID-19). To date, no study has evaluated the association between MC, its subtypes of collagenous colitis (CC) and lymphocytic colitis (LC), and COVID-19. We therefore sought to examine the risk of severe COVID-19 in patients with MC as compared with the general population. We also compared the frequency of a risk variant from the 3p21.31 gene cluster associated with severe COVID-19 3 across MC subtypes.