TY - JOUR
T1 - Association between clusters of back and joint pain with opioid use in middle-aged community-based women
T2 - a prospective cohort study
AU - Hussain, Sultana Monira
AU - Wang, Yuanyuan
AU - Peeters, Geeske
AU - Wluka, Anita E.
AU - Mishra, Gita D.
AU - Teede, Helena
AU - Urquhart, Donna
AU - Brown, Wendy J.
AU - Cicuttini, Flavia M.
N1 - Funding Information:
The Australian Longitudinal Study on Women’s Health (ALSWH), which was conceived and developed by groups of interdisciplinary researchers at the universities of Newcastle and Queensland, is funded by the Commonwealth Department of Health. The authors acknowledge the Australian Government Department of Health for providing MBS data, and the Australian Institute of Health and Welfare (AIHW) as the integrating authority. The linkage study between ALSWH and PBS is supported by the Alfred Foundation research grant and the MMRF (Monash Partners Rapid Translation Grant 2017). SMH is the recipient of National Health and Medical Research Council (NHMRC) Early Career Fellowship (APP1142198), YW is the recipients of NHMRC Translating Research Into Practice (APP1168185). AW is the recipient Royal Australian College of Physicians Fellows Career Development Fellowship. DMU is the recipient of an NHMRC Career Development Fellowship (Level 2 APP1142809). GDM is supported by NHMRC Principal Research Fellowship (APP1121844). The funding sources had no role in the design, conduct, or reporting of the study or the decision to submit the manuscript for publication.
Publisher Copyright:
© 2021, The Author(s).
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/10/9
Y1 - 2021/10/9
N2 - Background: To determine the relationship between clusters of back pain and joint pain and prescription opioid dispensing. Methods: Of 11,221 middle-aged participants from the Australian Longitudinal Study of Women’s Health, clusters of back pain and joint pain from 2001 to 2013 were identified using group-based trajectory modelling. Prescription opioid dispensing from 2003 to 2015 was identified by linking the cohort to Pharmaceutical Benefit Scheme dispensing data. Multinomial logistic regression was used to examine the association between back pain and joint pain clusters and dispensing of prescription opioids. The proportion of opioids dispensed in the population attributable to back and join pain was calculated. Results: Over 12 years, 68.5 and 72.0% women reported frequent or persistent back pain and joint pain, respectively. There were three clusters (‘none or infrequent’, ‘frequent’ and ‘persistent’) for both back pain and joint pain. Those in the persistent back pain cluster had a 6.33 (95%CI 4.38-9.16) times increased risk of having > 50 opioid prescriptions and those in persistent joint pain cluster had a 6.19 (95%CI 4.18-9.16) times increased risk of having > 50 opioid prescriptions. Frequent and persistent back and joint pain clusters together explained 41.7% (95%CI 34.9-47.8%) of prescription opioid dispensing. Women in the frequent and persistent back pain and joint pain clusters were less educated and reported more depression and physical inactivity. Conclusion: Back pain and joint pain are major contributors to opioid prescription dispensing in community-based middle-aged women. Additional approaches to reduce opioid use, targeted at those with frequent and persistent back pain and joint pain, will be important in order to reduce the use of opioids and their consequent harm in this population.
AB - Background: To determine the relationship between clusters of back pain and joint pain and prescription opioid dispensing. Methods: Of 11,221 middle-aged participants from the Australian Longitudinal Study of Women’s Health, clusters of back pain and joint pain from 2001 to 2013 were identified using group-based trajectory modelling. Prescription opioid dispensing from 2003 to 2015 was identified by linking the cohort to Pharmaceutical Benefit Scheme dispensing data. Multinomial logistic regression was used to examine the association between back pain and joint pain clusters and dispensing of prescription opioids. The proportion of opioids dispensed in the population attributable to back and join pain was calculated. Results: Over 12 years, 68.5 and 72.0% women reported frequent or persistent back pain and joint pain, respectively. There were three clusters (‘none or infrequent’, ‘frequent’ and ‘persistent’) for both back pain and joint pain. Those in the persistent back pain cluster had a 6.33 (95%CI 4.38-9.16) times increased risk of having > 50 opioid prescriptions and those in persistent joint pain cluster had a 6.19 (95%CI 4.18-9.16) times increased risk of having > 50 opioid prescriptions. Frequent and persistent back and joint pain clusters together explained 41.7% (95%CI 34.9-47.8%) of prescription opioid dispensing. Women in the frequent and persistent back pain and joint pain clusters were less educated and reported more depression and physical inactivity. Conclusion: Back pain and joint pain are major contributors to opioid prescription dispensing in community-based middle-aged women. Additional approaches to reduce opioid use, targeted at those with frequent and persistent back pain and joint pain, will be important in order to reduce the use of opioids and their consequent harm in this population.
UR - http://www.scopus.com/inward/record.url?scp=85116761189&partnerID=8YFLogxK
U2 - 10.1186/s12891-021-04741-4
DO - 10.1186/s12891-021-04741-4
M3 - Article
C2 - 34627214
AN - SCOPUS:85116761189
VL - 22
JO - BMC Musculoskeletal Disorders
JF - BMC Musculoskeletal Disorders
SN - 1471-2474
IS - 1
M1 - 863
ER -