TY - JOUR
T1 - Association between brain health outcomes and metabolic risk factors in persons with diabetes
AU - Reynolds, Evan L.
AU - Votruba, Kristen
AU - Jack, Clifford R.
AU - Beare, Richard
AU - Reid, Robert I.
AU - Preboske, Gregory M.
AU - Waseta, Camille
AU - Pop-Busui, Rodica
AU - Nelson, Robert G.
AU - Callaghan, Brian C.
AU - Feldman, Eva L.
N1 - Funding Information:
Dr. Reynolds is supported by the NIH NIDDK (K99DK129785). Dr. Jack is supported by the NIH and the Alexander Family Professorship at Mayo Clinic. Ms. Waseta is supported by The Intramural Research Program of the National Institute for Diabetes, Digestive and Kidney Disease. Dr. Pop‐Busui is supported is supported by the NIH NIDDK (R01DK107956, U01DK119083, 1U01 DK0945157, R01DK116723) and the JDRF Center of Excellence at the University of Michigan. Dr. Nelson is supported by The Intramural Research Program of the National Institute for Diabetes, Digestive and Kidney Disease. Dr. Callaghan is supported by the NIH NIDDK (R01DK115687). Dr. Feldman is supported by the NIH (U01AG057562, U24DK115255, R01DK130913), the Robert E. Nederlander Sr. Program for Alzheimer's Research, the Andrea and Lawrence A. Wolfe Brain Health Initiative Fund, the A. Alfred Taubman Medical Research Institute, and the NeuroNetwork for Emerging Therapies.
Publisher Copyright:
© 2023 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.
PY - 2023/10
Y1 - 2023/10
N2 - We performed a cross-sectional study to determine associations between cognition and MRI-derived brain outcomes, with obesity, diabetes duration, and metabolic risk factors in 51 Pima American Indians with longstanding type 2 diabetes (T2d) (mean [SD] age: 48.4 [11.3] years, T2d duration: 20.1 [9.1] years). Participants had similar cognition (NIH Toolbox Cognition Battery composite: 45.3 [9.8], p = 0.64, n = 51) compared to normative data. T2d duration, but not other metabolic risk factors, associated with decreased cortical thickness (Point Estimate (PE): −0.0061, 95%CI: −0.0113, −0.0009, n = 45), gray matter volume (PE: −830.39, 95%CI: −1503.14, −157.64, n = 45), and increased white matter hyperintensity volume (PE: 0.0389, 95%CI: 0.0049, 0.0729, n = 45).
AB - We performed a cross-sectional study to determine associations between cognition and MRI-derived brain outcomes, with obesity, diabetes duration, and metabolic risk factors in 51 Pima American Indians with longstanding type 2 diabetes (T2d) (mean [SD] age: 48.4 [11.3] years, T2d duration: 20.1 [9.1] years). Participants had similar cognition (NIH Toolbox Cognition Battery composite: 45.3 [9.8], p = 0.64, n = 51) compared to normative data. T2d duration, but not other metabolic risk factors, associated with decreased cortical thickness (Point Estimate (PE): −0.0061, 95%CI: −0.0113, −0.0009, n = 45), gray matter volume (PE: −830.39, 95%CI: −1503.14, −157.64, n = 45), and increased white matter hyperintensity volume (PE: 0.0389, 95%CI: 0.0049, 0.0729, n = 45).
UR - http://www.scopus.com/inward/record.url?scp=85166399914&partnerID=8YFLogxK
U2 - 10.1002/acn3.51859
DO - 10.1002/acn3.51859
M3 - Article
C2 - 37518982
AN - SCOPUS:85166399914
SN - 2328-9503
VL - 10
SP - 1891
EP - 1898
JO - Annals of Clinical and Translational Neurology
JF - Annals of Clinical and Translational Neurology
IS - 10
ER -
