Association between ABCB1 C3435T polymorphism and drug-resistant epilepsy in Han Chinese

Patrick Kwan, Larry Baum, Virginia Wong, Ping Wing Ng, Colin HT Lui, Ngai Chuen Sin, Andrew C.F. Hui, Evelyn Yu, Lawrence K.S. Wong

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Abstract

There is accumulating evidence to suggest that overexpression of efflux drug transporters at the blood-brain barrier, by reducing antiepileptic drug (AED) accumulation in the seizure foci, contributes to drug resistance in epilepsy. P-glycoprotein, encoded by the ABCB1 gene, is the most studied drug transporter. There are conflicting data as to whether the CC genotype of the ABCB1 3435C > T polymorphism is associated with drug resistance in Caucasian patients with epilepsy. We investigated this association in ethnic Chinese. ABCB1 3435C > T was genotyped in 746 Han Chinese patients with epilepsy and 179 controls. Patients with drug-resistant epilepsy were more likely to have the TT genotype compared with those with drug-responsive epilepsy (16.7% vs 7.4%, odds ratio = 2.5, 95% confidence interval = 1.4-4.6, P = 0.0009). Our results contrast with those of studies of Caucasians, and highlight the complexity of the possible role of this polymorphism in AED response in different ethnic populations.

Original languageEnglish
Pages (from-to)112-117
Number of pages6
JournalEpilepsy & Behavior
Volume11
Issue number1
DOIs
Publication statusPublished - 1 Aug 2007
Externally publishedYes

Keywords

  • ABCB1
  • Antiepileptic drugs
  • Chinese
  • Drug resistance
  • Drug transporters
  • Epilepsy
  • Genetic polymorphisms
  • MDR1
  • P-glycoprotein
  • Pharmacogenetics

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