Assisted reproductive technologies are associated with limited epigenetic variation at birth that largely resolves by adulthood.

Boris Novakovic, Sharon Lewis, Jane Halliday, Joanne Kennedy, David P Burgner, Anna Czajko, Bowon Kim, Alexandra Sexton-Oates, Markus Juonala, Karin Hammarberg, David J Amor, Lex W Doyle, Sarath Ranganathan, Liam Welsh, Michael Cheung, John McBain, Robert McLachlan, Richard Saffery

Research output: Contribution to journalArticleResearchpeer-review

Abstract

More than 7 million individuals have been conceived by Assisted Reproductive Technologies (ART) and there is clear evidence that ART is associated with a range of adverse early life outcomes, including rare imprinting disorders. The periconception period and early embryogenesis are associated with widespread epigenetic remodeling, which can be influenced by ART, with effects on the developmental trajectory in utero, and potentially on health throughout life. Here we profile genome-wide DNA methylation in blood collected in the newborn period and in adulthood (age 22–35 years) from a unique longitudinal cohort of ART-conceived individuals, previously shown to have no differences in health outcomes in early adulthood compared with non-ART-conceived individuals. We show evidence for specific ART-associated variation in methylation around birth, most of which occurred independently of embryo culturing. Importantly, ART-associated epigenetic variation at birth largely resolves by adulthood with no direct evidence that it impacts on development and health.
Original languageEnglish
Article number3922
Number of pages12
JournalNature Communications
Volume10
Issue number1
DOIs
Publication statusPublished - 2 Sep 2019

Cite this

Novakovic, Boris ; Lewis, Sharon ; Halliday, Jane ; Kennedy, Joanne ; Burgner, David P ; Czajko, Anna ; Kim, Bowon ; Sexton-Oates, Alexandra ; Juonala, Markus ; Hammarberg, Karin ; Amor, David J ; Doyle, Lex W ; Ranganathan, Sarath ; Welsh, Liam ; Cheung, Michael ; McBain, John ; McLachlan, Robert ; Saffery, Richard. / Assisted reproductive technologies are associated with limited epigenetic variation at birth that largely resolves by adulthood. In: Nature Communications. 2019 ; Vol. 10, No. 1.
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abstract = "More than 7 million individuals have been conceived by Assisted Reproductive Technologies (ART) and there is clear evidence that ART is associated with a range of adverse early life outcomes, including rare imprinting disorders. The periconception period and early embryogenesis are associated with widespread epigenetic remodeling, which can be influenced by ART, with effects on the developmental trajectory in utero, and potentially on health throughout life. Here we profile genome-wide DNA methylation in blood collected in the newborn period and in adulthood (age 22–35 years) from a unique longitudinal cohort of ART-conceived individuals, previously shown to have no differences in health outcomes in early adulthood compared with non-ART-conceived individuals. We show evidence for specific ART-associated variation in methylation around birth, most of which occurred independently of embryo culturing. Importantly, ART-associated epigenetic variation at birth largely resolves by adulthood with no direct evidence that it impacts on development and health.",
author = "Boris Novakovic and Sharon Lewis and Jane Halliday and Joanne Kennedy and Burgner, {David P} and Anna Czajko and Bowon Kim and Alexandra Sexton-Oates and Markus Juonala and Karin Hammarberg and Amor, {David J} and Doyle, {Lex W} and Sarath Ranganathan and Liam Welsh and Michael Cheung and John McBain and Robert McLachlan and Richard Saffery",
year = "2019",
month = "9",
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doi = "10.1038/s41467-019-11929-9",
language = "English",
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Novakovic, B, Lewis, S, Halliday, J, Kennedy, J, Burgner, DP, Czajko, A, Kim, B, Sexton-Oates, A, Juonala, M, Hammarberg, K, Amor, DJ, Doyle, LW, Ranganathan, S, Welsh, L, Cheung, M, McBain, J, McLachlan, R & Saffery, R 2019, 'Assisted reproductive technologies are associated with limited epigenetic variation at birth that largely resolves by adulthood.', Nature Communications, vol. 10, no. 1, 3922. https://doi.org/10.1038/s41467-019-11929-9

Assisted reproductive technologies are associated with limited epigenetic variation at birth that largely resolves by adulthood. / Novakovic, Boris; Lewis, Sharon; Halliday, Jane; Kennedy, Joanne; Burgner, David P; Czajko, Anna ; Kim, Bowon ; Sexton-Oates, Alexandra; Juonala, Markus; Hammarberg, Karin; Amor, David J; Doyle, Lex W; Ranganathan, Sarath; Welsh, Liam; Cheung, Michael ; McBain, John; McLachlan, Robert; Saffery, Richard.

In: Nature Communications, Vol. 10, No. 1, 3922, 02.09.2019.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Assisted reproductive technologies are associated with limited epigenetic variation at birth that largely resolves by adulthood.

AU - Novakovic, Boris

AU - Lewis, Sharon

AU - Halliday, Jane

AU - Kennedy, Joanne

AU - Burgner, David P

AU - Czajko, Anna

AU - Kim, Bowon

AU - Sexton-Oates, Alexandra

AU - Juonala, Markus

AU - Hammarberg, Karin

AU - Amor, David J

AU - Doyle, Lex W

AU - Ranganathan, Sarath

AU - Welsh, Liam

AU - Cheung, Michael

AU - McBain, John

AU - McLachlan, Robert

AU - Saffery, Richard

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AB - More than 7 million individuals have been conceived by Assisted Reproductive Technologies (ART) and there is clear evidence that ART is associated with a range of adverse early life outcomes, including rare imprinting disorders. The periconception period and early embryogenesis are associated with widespread epigenetic remodeling, which can be influenced by ART, with effects on the developmental trajectory in utero, and potentially on health throughout life. Here we profile genome-wide DNA methylation in blood collected in the newborn period and in adulthood (age 22–35 years) from a unique longitudinal cohort of ART-conceived individuals, previously shown to have no differences in health outcomes in early adulthood compared with non-ART-conceived individuals. We show evidence for specific ART-associated variation in methylation around birth, most of which occurred independently of embryo culturing. Importantly, ART-associated epigenetic variation at birth largely resolves by adulthood with no direct evidence that it impacts on development and health.

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