TY - JOUR
T1 - Assessment of the lateral diffusion and penetration of topically applied drugs in humans using a novel concentric tape stripping design
AU - Gee, Carol Maying
AU - Nicolazzo, Joseph
AU - Watkinson, A C
AU - Finnin, Barrie Charles
PY - 2012
Y1 - 2012
N2 - Transdermal and topical drug delivery are methods by
which an active drug is applied onto the skin surface for
the purpose of systemic or local treatment, respectively. For
a transdermally or topically applied drug to become bioavailable,
it must follow a tortuous route of penetration
around the corneocytes and through the interceulluar lipid
domains of the stratum corneum (SC). In this respect, the
inherent barrier function of the SC limits the usefulness of
this route of delivery.
AB - Transdermal and topical drug delivery are methods by
which an active drug is applied onto the skin surface for
the purpose of systemic or local treatment, respectively. For
a transdermally or topically applied drug to become bioavailable,
it must follow a tortuous route of penetration
around the corneocytes and through the interceulluar lipid
domains of the stratum corneum (SC). In this respect, the
inherent barrier function of the SC limits the usefulness of
this route of delivery.
UR - http://link.springer.com/content/pdf/10.1007%2Fs11095-012-0731-7
U2 - 10.1007/s11095-012-0731-7
DO - 10.1007/s11095-012-0731-7
M3 - Article
VL - 29
SP - 2035
EP - 2046
JO - Pharmaceutical Research
JF - Pharmaceutical Research
SN - 0724-8741
IS - 8
ER -