Assessment of the lateral diffusion and penetration of topically applied drugs in humans using a novel concentric tape stripping design

Carol Maying Gee, Joseph Nicolazzo, A C Watkinson, Barrie Charles Finnin

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Abstract

Transdermal and topical drug delivery are methods by which an active drug is applied onto the skin surface for the purpose of systemic or local treatment, respectively. For a transdermally or topically applied drug to become bioavailable, it must follow a tortuous route of penetration around the corneocytes and through the interceulluar lipid domains of the stratum corneum (SC). In this respect, the inherent barrier function of the SC limits the usefulness of this route of delivery.
Original languageEnglish
Pages (from-to)2035 - 2046
Number of pages12
JournalPharmaceutical Research
Volume29
Issue number8
DOIs
Publication statusPublished - 2012

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