TY - JOUR
T1 - Assessment of intravenous immunoglobulin non-responders in Kawasaki disease
AU - Hwang, Ja Young
AU - Lee, Kyung Yil
AU - Rhim, Jung Woo
AU - Youn, You Sook
AU - Oh, Jin Hee
AU - Han, Ji Whan
AU - Lee, Joon Sung
AU - Burgner, David
PY - 2011/11
Y1 - 2011/11
N2 - The authors compared pre-treatment and posttreatment characteristics of 206 prospectively enrolled patients with Kawasaki disease (KD) responsive to intravenous immunoglobulin (IVIG) with those of 23 (10% of total) IVIG non-responders. Demographic characteristics were similar in both groups. Compared to IVIG responders, non-responders had a longer total duration of fever and a higher incidence of coronary artery lesions. Prior to IVIG, non-responders had higher neutrophil differential and C-reactive protein, and lower cholesterol. 24 hours after the IVIG infusion, a total leucocyte count >13.1×10 9/l, neutrophil differential >51% and total protein <72 g/l showed reasonable sensitivity (91%, 91% and 64%, respectively) and specificity (89%, 76% and 78%, respectively) as independent characteristics of non-response to IVIG. Laboratory parameters before and shortly after IVIG may reflect the severity of inflammation in KD patients and assist in informing further management.
AB - The authors compared pre-treatment and posttreatment characteristics of 206 prospectively enrolled patients with Kawasaki disease (KD) responsive to intravenous immunoglobulin (IVIG) with those of 23 (10% of total) IVIG non-responders. Demographic characteristics were similar in both groups. Compared to IVIG responders, non-responders had a longer total duration of fever and a higher incidence of coronary artery lesions. Prior to IVIG, non-responders had higher neutrophil differential and C-reactive protein, and lower cholesterol. 24 hours after the IVIG infusion, a total leucocyte count >13.1×10 9/l, neutrophil differential >51% and total protein <72 g/l showed reasonable sensitivity (91%, 91% and 64%, respectively) and specificity (89%, 76% and 78%, respectively) as independent characteristics of non-response to IVIG. Laboratory parameters before and shortly after IVIG may reflect the severity of inflammation in KD patients and assist in informing further management.
UR - http://www.scopus.com/inward/record.url?scp=80054742591&partnerID=8YFLogxK
U2 - 10.1136/adc.2010.184101
DO - 10.1136/adc.2010.184101
M3 - Article
C2 - 20551193
AN - SCOPUS:80054742591
VL - 96
SP - 1088
EP - 1090
JO - Archives of Disease in Childhood
JF - Archives of Disease in Childhood
SN - 0003-9888
IS - 11
ER -