Assessment of double-barrelled heck cyclizations as a means for construction of the 14-Phenyl-8,9-dihydro6H-[1]benzopyrano[4′,3′:4,5]pyrrolo[2,1-a] isoquinolin-6-one core associated with certain members of the lamellarin class of marine natural product

Martin G. Banwell, Bernard L. Flynn, David C.R. Hockless, Robert W. Longmore, A. David Rae

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Abstract

The 1,2,4-trisubstituted pyrrole (4), which is readily prepared from pyrrole itself, undergoes doublebarrelled Heck cyclizations to give, inter alia, compounds (3) and (17) for which crystal structures have been determined. Product (3) constitutes the core associated with several key members, e.g. (1) and (2), of the lamellarin class of marine alkaloid.

Original languageEnglish
JournalAustralian Journal of Chemistry
Volume52
Issue number8
Publication statusPublished - 1 Dec 1999
Externally publishedYes

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