TY - JOUR
T1 - Assessment of cognitive symptoms in prodromal and early Huntington disease
AU - Vaccarino, Anthony L
AU - Sills, Terrence L
AU - Anderson, Karen E
AU - Borowsky, Beth
AU - Craufurd, David O
AU - Giuliano, Joseph
AU - Goodman, LaVonne Veatch
AU - Guttman, Mark
AU - Kupchak, Peter
AU - Ho, Aileen K
AU - Paulsen, Jane S
AU - Stout, Julie C
AU - Van Kammen, Daniel P
AU - Evans, Kenneth R
PY - 2011/7/29
Y1 - 2011/7/29
N2 - The Functional Rating Scale Taskforce for pre-Huntington Disease (FuRST-pHD) is a multinational, multidisciplinary initiative with the goal of developing a data-driven, comprehensive, psychometrically sound, rating scale for assessing symptoms and functional ability in prodromal and early Huntington disease (HD) gene expansion carriers. The process involves input from numerous sources to identify relevant symptom domains, including HD individuals, caregivers, and experts from a variety of fields, as well as knowledge gained from the analysis of data from ongoing large-scale studies in HD using existing clinical scales. This is an iterative process in which an ongoing series of field tests in prodromal (prHD) and early HD individuals provides the team with data on which to make decisions regarding which questions should undergo further development or testing and which should be excluded. We report here the development and assessment of the first iteration of interview questions aimed to assess cognitive symptoms in prHD and early HD individuals.
AB - The Functional Rating Scale Taskforce for pre-Huntington Disease (FuRST-pHD) is a multinational, multidisciplinary initiative with the goal of developing a data-driven, comprehensive, psychometrically sound, rating scale for assessing symptoms and functional ability in prodromal and early Huntington disease (HD) gene expansion carriers. The process involves input from numerous sources to identify relevant symptom domains, including HD individuals, caregivers, and experts from a variety of fields, as well as knowledge gained from the analysis of data from ongoing large-scale studies in HD using existing clinical scales. This is an iterative process in which an ongoing series of field tests in prodromal (prHD) and early HD individuals provides the team with data on which to make decisions regarding which questions should undergo further development or testing and which should be excluded. We report here the development and assessment of the first iteration of interview questions aimed to assess cognitive symptoms in prHD and early HD individuals.
UR - http://currents.plos.org//hd/article/assessment-of-cognitive-symptoms-in-prodromal-and-early-huntington-disease/pdf
U2 - 10.1371/currents.RRN1250
DO - 10.1371/currents.RRN1250
M3 - Article
C2 - 22120841
SN - 2157-3999
VL - 3
JO - PLoS Currents: Huntington Disease
JF - PLoS Currents: Huntington Disease
M1 - RRN1250
ER -