Assessment of angiogenesis modulators in pregnant women with pre-eclampsia: a case–control study

Guilhermo Justino Mundim, Marina Carvalho Paschoini, Edward Araujo Júnior, Fabricio Da Silva Costa, Virmondes Rodrigues Júnior

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19 Citations (Scopus)

Abstract

Purpose: This study aimed to evaluate the serum concentration of factors associated with placental angiogenesis in pre-eclamptic and normotensive pregnant women. Methods: This was a prospective, cross-sectional, case–control study in which the pro-angiogenic factors PlGF, VEGF and IL-10, and the anti-angiogenic factors IL-6, IL-17 and TNF-α of 55 pregnant women (31 with pre-eclampsia—PE and 24 normotensive), with gestational age ≥20 weeks, were measured in maternal blood through the enzyme-linked immunosorbent assay (ELISA). The Mann–Whitney and Kruskal–Wallis tests were used for comparison between groups. Results: Serum PIGF was reduced in the group of pregnant women with PE when compared with the normotensive women (493.2 ± 55.1 pg/mL vs. 4.4 ± 26.5 pg/mL; p < 0.001). There was no significant difference in PlGF levels in the pre-eclamptic pregnant women in relation to gestational age or proteinuria levels (p > 0.05). The serum levels of VEGF, IL-17, IL-10 and TNF-α were lower in the pregnant women with PE when compared with their normotensive peers, while the IL-6 levels were higher; however, this difference was not statistically significant (p > 0.05). Conclusion: Serum PlGF levels were reduced in the pregnant women with PE and were unrelated to disease severity. Serum levels of VEGF, IL-17, IL-10 and TNF-α were reduced in the pre-eclamptic pregnant women when compared with their normotensive peers, without statistically significant differences.

Original languageEnglish
Pages (from-to)369-375
Number of pages7
JournalArchives of Gynecology and Obstetrics
Volume293
Issue number2
DOIs
Publication statusPublished - Feb 2016
Externally publishedYes

Keywords

  • Angiogenesis
  • Cytokines
  • Placenta
  • Pre-eclampsia

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