TY - JOUR
T1 - Assessment of a four-view mammographic image feature based fusion model to predict near-term breast cancer risk
AU - Tan, Maxine
AU - Pu, Jiantao
AU - Cheng, Samuel
AU - Liu, Hong
AU - Zheng, Bin
N1 - Publisher Copyright:
© 2015, Biomedical Engineering Society.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2015/10/22
Y1 - 2015/10/22
N2 - The purpose of this study was to develop and assess a new quantitative four-view mammographic image feature based fusion model to predict the near-term breast cancer risk of the individual women after a negative screening mammography examination of interest. The dataset included fully-anonymized mammograms acquired on 870 women with two sequential full-field digital mammography examinations. For each woman, the first “prior” examination in the series was interpreted as negative (not recalled) during the original image reading. In the second “current” examination, 430 women were diagnosed with pathology verified cancers and 440 remained negative (“cancer-free”). For each of four bilateral craniocaudal and mediolateral oblique view images of left and right breasts, we computed and analyzed eight groups of global mammographic texture and tissue density image features. A risk prediction model based on three artificial neural networks was developed to fuse image features computed from two bilateral views of four images. The risk model performance was tested using a ten-fold cross-validation method and a number of performance evaluation indices including the area under the receiver operating characteristic curve (AUC) and odds ratio (OR). The highest AUC = 0.725 ± 0.026 was obtained when the model was trained by gray-level run length statistics texture features computed on dense breast regions, which was significantly higher than the AUC values achieved using the model trained by only two bilateral one-view images (p < 0.02). The adjustable OR values monotonically increased from 1.0 to 11.8 as model-generated risk score increased. The regression analysis of OR values also showed a significant increase trend in slope (p < 0.01). As a result, this preliminary study demonstrated that a new four-view mammographic image feature based risk model could provide useful and supplementary image information to help predict the near-term breast cancer risk.
AB - The purpose of this study was to develop and assess a new quantitative four-view mammographic image feature based fusion model to predict the near-term breast cancer risk of the individual women after a negative screening mammography examination of interest. The dataset included fully-anonymized mammograms acquired on 870 women with two sequential full-field digital mammography examinations. For each woman, the first “prior” examination in the series was interpreted as negative (not recalled) during the original image reading. In the second “current” examination, 430 women were diagnosed with pathology verified cancers and 440 remained negative (“cancer-free”). For each of four bilateral craniocaudal and mediolateral oblique view images of left and right breasts, we computed and analyzed eight groups of global mammographic texture and tissue density image features. A risk prediction model based on three artificial neural networks was developed to fuse image features computed from two bilateral views of four images. The risk model performance was tested using a ten-fold cross-validation method and a number of performance evaluation indices including the area under the receiver operating characteristic curve (AUC) and odds ratio (OR). The highest AUC = 0.725 ± 0.026 was obtained when the model was trained by gray-level run length statistics texture features computed on dense breast regions, which was significantly higher than the AUC values achieved using the model trained by only two bilateral one-view images (p < 0.02). The adjustable OR values monotonically increased from 1.0 to 11.8 as model-generated risk score increased. The regression analysis of OR values also showed a significant increase trend in slope (p < 0.01). As a result, this preliminary study demonstrated that a new four-view mammographic image feature based risk model could provide useful and supplementary image information to help predict the near-term breast cancer risk.
KW - Breast cancer
KW - Computer-aided detection (CAD)
KW - Full-field digital mammography (FFDM)
KW - Mammographic density feature analysis
KW - Near-term breast cancer risk stratification
UR - http://www.scopus.com/inward/record.url?scp=84941878738&partnerID=8YFLogxK
U2 - 10.1007/s10439-015-1316-5
DO - 10.1007/s10439-015-1316-5
M3 - Article
C2 - 25851469
AN - SCOPUS:84941878738
VL - 43
SP - 2416
EP - 2428
JO - Annals of Biomedical Engineering
JF - Annals of Biomedical Engineering
SN - 0090-6964
IS - 10
ER -
