TY - JOUR
T1 - Assessment and management of musculoskeletal disorders among patients living with HIV
AU - Walker-Bone, Karen
AU - Doherty, Erin
AU - Sanyal, Kaushik
AU - Churchill, Duncan
N1 - Funding Information:
1Arthritis Research UK/MRC Centre for Musculoskeletal Health and Work, 2Medical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, 3Department of Medicine, Royal United Hospitals Bath NHS Foundation Trust, Bath, 4Department of Rheumatology, Western Sussex Hospitals NHS Foundation Trust, St Richard’s Hospital, Chichester and 5Lawson Unit, Brighton & Sussex University Hospitals NHS Trust, Brighton, UK Submitted 3 May 2016; revised version accepted 14 October 2016 Correspondence to: Karen Walker-Bone, Medical Research Council Lifecourse Epidemiology Unit, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK. E-mail: [email protected]
Publisher Copyright:
© The Author 2017. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved.
PY - 2017/10
Y1 - 2017/10
N2 - HIV is a global pandemic. However, anti-retroviral therapy has transformed the prognosis and, providing compliance is good, a normal life expectancy can be anticipated. This has led to increasing numbers of people with chronic prevalent, treated infection living to older ages. Musculoskeletal pain is commonly reported by HIV patients and, with resumption of near-normal immune function, HIV-infected patients develop inflammatory rheumatic diseases that require assessment and management in rheumatology clinics. Moreover, it is becoming apparent that avascular necrosis and osteoporosis are common comorbidities of HIV. This review will contextualize the prevalence of musculoskeletal symptoms in HIV, informed by data from a UK-based clinic, and will discuss the management of active inflammatory rheumatic diseases among HIV-infected patients taking anti-retroviral therapy, highlighting known drug interactions.
AB - HIV is a global pandemic. However, anti-retroviral therapy has transformed the prognosis and, providing compliance is good, a normal life expectancy can be anticipated. This has led to increasing numbers of people with chronic prevalent, treated infection living to older ages. Musculoskeletal pain is commonly reported by HIV patients and, with resumption of near-normal immune function, HIV-infected patients develop inflammatory rheumatic diseases that require assessment and management in rheumatology clinics. Moreover, it is becoming apparent that avascular necrosis and osteoporosis are common comorbidities of HIV. This review will contextualize the prevalence of musculoskeletal symptoms in HIV, informed by data from a UK-based clinic, and will discuss the management of active inflammatory rheumatic diseases among HIV-infected patients taking anti-retroviral therapy, highlighting known drug interactions.
KW - Biologics
KW - Disease-modifying anti-rheumatic drugs
KW - HIV
KW - Inflammatory rheumatic disease
KW - Musculoskeletal
UR - http://www.scopus.com/inward/record.url?scp=85030748815&partnerID=8YFLogxK
U2 - 10.1093/rheumatology/kew418
DO - 10.1093/rheumatology/kew418
M3 - Review Article
C2 - 28013196
AN - SCOPUS:85030748815
SN - 1462-0324
VL - 56
SP - 1648
EP - 1661
JO - Rheumatology
JF - Rheumatology
IS - 10
ER -