Abstract
High-heat processed foods undergo chemical modifications that cause proteins to become resistant to enzymatic digestion. These resistant proteins reach the colon where they are fermented by gut microbiota. Excess resistant protein fermentation may be harmful to health via forfeited protein nutrition, altering gut microbial composition, and production of potentially harmful fermentation metabolites, such as phenols, indoles and amines. Dietary-resistant proteins are present in ultra-processed foods, processed forms of infant formulae, and ‘meat’ substitutes made from processed plant proteins. This study will determine the effects of a high-resistant protein diet on growth, gut microbiome, protein fermentation metabolites, and biomarkers of health status. Weanling pigs are fed a standard (n = 4) or resistant protein (n = 4) diet, which is approximately half as digestible and designed to enter the colon for microbial fermentation, for 4 weeks (both 21% w/w protein). Faecal samples are collected to assess the microbiome via 16S rRNA gene bioinformatics. Blood samples are collected to measure circulating metabolites and biomarkers via metabolomics analysis. Pig weight and feed intake is monitored throughout the study. The results from this study will shed light on the mechanisms that link diets high in resistant proteins with potential adverse health outcomes.
| Original language | English |
|---|---|
| Article number | 3.51 |
| Pages (from-to) | 50-51 |
| Number of pages | 2 |
| Journal | Proceedings |
| Volume | 80 |
| Issue number | 1 |
| Publication status | Published - 1 Mar 2022 |
| Event | Annual Scientific Meeting of the Nutrition-Society-of-Australia 2021: Opportunities for Nutrition Science in a New Era - virtual, Australia Duration: 2 Dec 2021 → 3 Dec 2021 Conference number: 45th https://www.mdpi.com/2504-3900/80/1/2 (The 45th Annual Scientific Meeting of the Nutrition Society of Australia was held virtually from 2–3 December 2021. The theme of the meeting was Nutrition: Opportunities for Nutrition Science in a New Era. Abstracts were submitted from 13 countries. A total of 326 registrants attended the conference, and 134 papers were presented consisting of 6 plenary, 54 oral and 74 poster presentations. This issue presents the proceedings of this meeting in the form of abstracts for papers presented at the conference) https://www.nsa.asn.au/events/annual-scientific-meeting-2021/ |