Assessing receptivity of the human endometrium to improve outcomes of fertility treatment

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Abstract

Despite considerable improvements in assessment of embryo quality in infertility clinics, outcomes in terms of take-home baby rate have not improved substantially. Failure of the endometrium to achieve receptivity and the timing of the receptive period are now recognised as important issues in the success of IVF.Indeed, immunohistochemical and morphological studies show that the endometrium is highly disturbed in any cycle in which ovulation induction is performed,leading to recommendations that all embryos be frozen and replaced in anon-stimulation cycle. Assessment of any woman for endometrial receptivity either in cycles prior to treatment or testing for the potential for an embryo to implant in the cycle of transfer is urgently needed. However, careful consideration must be given to issues such as sampling, timing and rapid delivery of results as well as the best biomarkers, to enable in-clinic decision-making. Here these issues are considered, along with how endometrial receptivity testing might best be performed to optimise outcomes of infertility treatment.
Original languageEnglish
Title of host publicationUterine Endometrial Function
EditorsHideharu Kanzaki
Place of PublicationTokyo Japan
PublisherSpringer
Chapter3
Pages27-48
Number of pages21
ISBN (Electronic)9784431559726
ISBN (Print)9784431559702
DOIs
Publication statusPublished - 2016

Keywords

  • Endometrial receptivity
  • Biomarkers
  • IVF success

Cite this

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title = "Assessing receptivity of the human endometrium to improve outcomes of fertility treatment",
abstract = "Despite considerable improvements in assessment of embryo quality in infertility clinics, outcomes in terms of take-home baby rate have not improved substantially. Failure of the endometrium to achieve receptivity and the timing of the receptive period are now recognised as important issues in the success of IVF.Indeed, immunohistochemical and morphological studies show that the endometrium is highly disturbed in any cycle in which ovulation induction is performed,leading to recommendations that all embryos be frozen and replaced in anon-stimulation cycle. Assessment of any woman for endometrial receptivity either in cycles prior to treatment or testing for the potential for an embryo to implant in the cycle of transfer is urgently needed. However, careful consideration must be given to issues such as sampling, timing and rapid delivery of results as well as the best biomarkers, to enable in-clinic decision-making. Here these issues are considered, along with how endometrial receptivity testing might best be performed to optimise outcomes of infertility treatment.",
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author = "Edgell, {Tracey J.} and Jemma Evans and Rombauts, {Luk J.R.} and Vollenhoven, {Beverley J.} and Salamonsen, {Lois Adrienne}",
year = "2016",
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pages = "27--48",
editor = "Hideharu Kanzaki",
booktitle = "Uterine Endometrial Function",
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Assessing receptivity of the human endometrium to improve outcomes of fertility treatment. / Edgell, Tracey J.; Evans, Jemma; Rombauts, Luk J.R.; Vollenhoven, Beverley J.; Salamonsen, Lois Adrienne.

Uterine Endometrial Function. ed. / Hideharu Kanzaki. Tokyo Japan : Springer, 2016. p. 27-48.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

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AB - Despite considerable improvements in assessment of embryo quality in infertility clinics, outcomes in terms of take-home baby rate have not improved substantially. Failure of the endometrium to achieve receptivity and the timing of the receptive period are now recognised as important issues in the success of IVF.Indeed, immunohistochemical and morphological studies show that the endometrium is highly disturbed in any cycle in which ovulation induction is performed,leading to recommendations that all embryos be frozen and replaced in anon-stimulation cycle. Assessment of any woman for endometrial receptivity either in cycles prior to treatment or testing for the potential for an embryo to implant in the cycle of transfer is urgently needed. However, careful consideration must be given to issues such as sampling, timing and rapid delivery of results as well as the best biomarkers, to enable in-clinic decision-making. Here these issues are considered, along with how endometrial receptivity testing might best be performed to optimise outcomes of infertility treatment.

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