Assembly-controlled permeability of layer-by-layer polymeric microcapsules using a tapered fluidized bed

Ka Fung Noi, Ali Roozmand, Mattias Björnmalm, Joseph Richardson, George V. Franks, Frank Caruso

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Nano- and microcapsules engineered through layer-by-layer (LbL) assembly are finding an increasingly large number of applications as catalysts, electrochemical biosensors, bioreactors, artificial cells and drug delivery vehicles. While centrifugation-based LbL assembly is the most common method for coating template particles and preparing capsules, it is a batch process and requires frequent intervention that renders the system challenging to automate and scale up. Here, we report the use of a tapered fluidized bed (TFB) for the preparation of multilayered polymer capsules. This is a significant improvement over our recent approach of fluidizing particles in cylindrical fluidized beds (CFB) for LbL assembly. We demonstrate that TFB is compatible with particles <3 μm in diameter (an order-of-magnitude improvement compared with CFB), which can be fluidized with minimal entrainment. Additionally, layering materials were expanded to include both electrostatic and hydrogen-bonding polymer pairs (e.g., poly(allylamine hydrochloride) (PAH) and poly(styrenesulfonate) (PSS), and thiol-modified poly(methacrylic acid) (PMASH) and poly(N-vinylpyrrolidone) (PVPON), respectively). Finally, differences between capsules prepared via centrifugation-based and TFB LbL assembly were investigated. The obtained TFB microcapsules demonstrate increased film thickness and roughness compared with those prepared using centrifugation-based LbL assembly. Furthermore, PMASH microcapsules exhibit lower swelling and permeability when prepared via TFB LbL assembly compared with centrifugation-based LbL assembly due to enhanced multilayer deposition, entanglement, and cross-linking. Therefore, polymeric capsules fabricated via TFB LbL assembly may be useful for encapsulation and retention of relatively low molecular weight (∼20 kDa) hydrophilic biomacromolecules to passively or responsively release the payload for drug delivery applications.

Original languageEnglish
Pages (from-to)27940-27947
Number of pages8
JournalACS Applied Materials and Interfaces
Volume7
Issue number50
DOIs
Publication statusPublished - 14 Dec 2015
Externally publishedYes

Keywords

  • layer-by-layer
  • microcapsule
  • nanofilm properties
  • permeability
  • swelling

Cite this

Noi, Ka Fung ; Roozmand, Ali ; Björnmalm, Mattias ; Richardson, Joseph ; Franks, George V. ; Caruso, Frank. / Assembly-controlled permeability of layer-by-layer polymeric microcapsules using a tapered fluidized bed. In: ACS Applied Materials and Interfaces. 2015 ; Vol. 7, No. 50. pp. 27940-27947.
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Assembly-controlled permeability of layer-by-layer polymeric microcapsules using a tapered fluidized bed. / Noi, Ka Fung; Roozmand, Ali; Björnmalm, Mattias; Richardson, Joseph; Franks, George V.; Caruso, Frank.

In: ACS Applied Materials and Interfaces, Vol. 7, No. 50, 14.12.2015, p. 27940-27947.

Research output: Contribution to journalArticleResearchpeer-review

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