Assay Guidance Manual: Quantitative Biology and Pharmacology in Preclinical Drug Discovery

Nathan P. Coussens, G. Sitta Sittampalam, Rajarshi Guha, Kyle Brimacombe, Abigail Grossman, Thomas D.Y. Chung, Jeffrey R. Weidner, Terry Riss, O. Joseph Trask, Douglas Auld, Jayme L. Dahlin, Viswanath Devanaryan, Timothy L. Foley, James McGee, Steven D. Kahl, Stephen C. Kales, Michelle Arkin, Jonathan Baell, Bruce Bejcek, Neely Gal-Edd & 25 others Marcie Glicksman, Joseph V. Haas, Philip W. Iversen, Marilu Hoeppner, Stacy Lathrop, Eric Sayers, Hanguan Liu, Bart Trawick, Julie McVey, Vance P. Lemmon, Zhuyin Li, Owen McManus, Lisa Minor, Andrew Napper, Mary Jo Wildey, Robert Pacifici, William W. Chin, Menghang Xia, Xin Xu, Madhu Lal-Nag, Matthew D. Hall, Sam Michael, James Inglese, Anton Simeonov, Christopher P. Austin

Research output: Contribution to journalArticleOtherpeer-review

Abstract

The Assay Guidance Manual (AGM) is an eBook of best practices for the design, development, and implementation of robust assays for early drug discovery. Initiated by pharmaceutical company scientists, the manual provides guidance for designing a “testing funnel” of assays to identify genuine hits using high-throughput screening (HTS) and advancing them through preclinical development. Combined with a workshop/tutorial component, the overall goal of the AGM is to provide a valuable resource for training translational scientists.

Original languageEnglish
Pages (from-to)461-470
Number of pages10
JournalClinical and Translational Science
Volume11
Issue number5
DOIs
Publication statusPublished - 1 Sep 2018

Cite this

Coussens, N. P., Sittampalam, G. S., Guha, R., Brimacombe, K., Grossman, A., Chung, T. D. Y., ... Austin, C. P. (2018). Assay Guidance Manual: Quantitative Biology and Pharmacology in Preclinical Drug Discovery. Clinical and Translational Science, 11(5), 461-470. https://doi.org/10.1111/cts.12570
Coussens, Nathan P. ; Sittampalam, G. Sitta ; Guha, Rajarshi ; Brimacombe, Kyle ; Grossman, Abigail ; Chung, Thomas D.Y. ; Weidner, Jeffrey R. ; Riss, Terry ; Trask, O. Joseph ; Auld, Douglas ; Dahlin, Jayme L. ; Devanaryan, Viswanath ; Foley, Timothy L. ; McGee, James ; Kahl, Steven D. ; Kales, Stephen C. ; Arkin, Michelle ; Baell, Jonathan ; Bejcek, Bruce ; Gal-Edd, Neely ; Glicksman, Marcie ; Haas, Joseph V. ; Iversen, Philip W. ; Hoeppner, Marilu ; Lathrop, Stacy ; Sayers, Eric ; Liu, Hanguan ; Trawick, Bart ; McVey, Julie ; Lemmon, Vance P. ; Li, Zhuyin ; McManus, Owen ; Minor, Lisa ; Napper, Andrew ; Wildey, Mary Jo ; Pacifici, Robert ; Chin, William W. ; Xia, Menghang ; Xu, Xin ; Lal-Nag, Madhu ; Hall, Matthew D. ; Michael, Sam ; Inglese, James ; Simeonov, Anton ; Austin, Christopher P. / Assay Guidance Manual : Quantitative Biology and Pharmacology in Preclinical Drug Discovery. In: Clinical and Translational Science. 2018 ; Vol. 11, No. 5. pp. 461-470.
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Coussens, NP, Sittampalam, GS, Guha, R, Brimacombe, K, Grossman, A, Chung, TDY, Weidner, JR, Riss, T, Trask, OJ, Auld, D, Dahlin, JL, Devanaryan, V, Foley, TL, McGee, J, Kahl, SD, Kales, SC, Arkin, M, Baell, J, Bejcek, B, Gal-Edd, N, Glicksman, M, Haas, JV, Iversen, PW, Hoeppner, M, Lathrop, S, Sayers, E, Liu, H, Trawick, B, McVey, J, Lemmon, VP, Li, Z, McManus, O, Minor, L, Napper, A, Wildey, MJ, Pacifici, R, Chin, WW, Xia, M, Xu, X, Lal-Nag, M, Hall, MD, Michael, S, Inglese, J, Simeonov, A & Austin, CP 2018, 'Assay Guidance Manual: Quantitative Biology and Pharmacology in Preclinical Drug Discovery' Clinical and Translational Science, vol. 11, no. 5, pp. 461-470. https://doi.org/10.1111/cts.12570

Assay Guidance Manual : Quantitative Biology and Pharmacology in Preclinical Drug Discovery. / Coussens, Nathan P.; Sittampalam, G. Sitta; Guha, Rajarshi; Brimacombe, Kyle; Grossman, Abigail; Chung, Thomas D.Y.; Weidner, Jeffrey R.; Riss, Terry; Trask, O. Joseph; Auld, Douglas; Dahlin, Jayme L.; Devanaryan, Viswanath; Foley, Timothy L.; McGee, James; Kahl, Steven D.; Kales, Stephen C.; Arkin, Michelle; Baell, Jonathan; Bejcek, Bruce; Gal-Edd, Neely; Glicksman, Marcie; Haas, Joseph V.; Iversen, Philip W.; Hoeppner, Marilu; Lathrop, Stacy; Sayers, Eric; Liu, Hanguan; Trawick, Bart; McVey, Julie; Lemmon, Vance P.; Li, Zhuyin; McManus, Owen; Minor, Lisa; Napper, Andrew; Wildey, Mary Jo; Pacifici, Robert; Chin, William W.; Xia, Menghang; Xu, Xin; Lal-Nag, Madhu; Hall, Matthew D.; Michael, Sam; Inglese, James; Simeonov, Anton; Austin, Christopher P.

In: Clinical and Translational Science, Vol. 11, No. 5, 01.09.2018, p. 461-470.

Research output: Contribution to journalArticleOtherpeer-review

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AU - Bejcek, Bruce

AU - Gal-Edd, Neely

AU - Glicksman, Marcie

AU - Haas, Joseph V.

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AU - Liu, Hanguan

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AU - McVey, Julie

AU - Lemmon, Vance P.

AU - Li, Zhuyin

AU - McManus, Owen

AU - Minor, Lisa

AU - Napper, Andrew

AU - Wildey, Mary Jo

AU - Pacifici, Robert

AU - Chin, William W.

AU - Xia, Menghang

AU - Xu, Xin

AU - Lal-Nag, Madhu

AU - Hall, Matthew D.

AU - Michael, Sam

AU - Inglese, James

AU - Simeonov, Anton

AU - Austin, Christopher P.

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Coussens NP, Sittampalam GS, Guha R, Brimacombe K, Grossman A, Chung TDY et al. Assay Guidance Manual: Quantitative Biology and Pharmacology in Preclinical Drug Discovery. Clinical and Translational Science. 2018 Sep 1;11(5):461-470. https://doi.org/10.1111/cts.12570