Reaction of 3-oxo-Δ4-steroids with calcium cyanide in N-methylpyrrolidone gives 5α- and 5β-cyano-3-oxo-steroids. The isomer ratio is close to 1:1 for androstenone, cholestenone and testosterone, and about 3:5 (α:β 5-cyanide) for progesterone.
|Number of pages||2|
|Journal||Journal of the Chemical Society C: Organic Chemistry|
|Publication status||Published - 1 Dec 1967|