Abstract
Reaction of 3-oxo-Δ4-steroids with calcium cyanide in N-methylpyrrolidone gives 5α- and 5β-cyano-3-oxo-steroids. The isomer ratio is close to 1:1 for androstenone, cholestenone and testosterone, and about 3:5 (α:β 5-cyanide) for progesterone.
| Original language | English |
|---|---|
| Pages (from-to) | 2465-2466 |
| Number of pages | 2 |
| Journal | Journal of the Chemical Society C: Organic Chemistry |
| DOIs | |
| Publication status | Published - 1 Dec 1967 |
| Externally published | Yes |
Cite this
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Aspects of stereochemistry. Part XX. The formation of 5-cyano-3-ketones from 3-oxo-Δ4-steroids. / Henbest, H. B.; Jackson, W. R.
In: Journal of the Chemical Society C: Organic Chemistry, 01.12.1967, p. 2465-2466.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Aspects of stereochemistry. Part XX. The formation of 5-cyano-3-ketones from 3-oxo-Δ4-steroids
AU - Henbest, H. B.
AU - Jackson, W. R.
PY - 1967/12/1
Y1 - 1967/12/1
N2 - Reaction of 3-oxo-Δ4-steroids with calcium cyanide in N-methylpyrrolidone gives 5α- and 5β-cyano-3-oxo-steroids. The isomer ratio is close to 1:1 for androstenone, cholestenone and testosterone, and about 3:5 (α:β 5-cyanide) for progesterone.
AB - Reaction of 3-oxo-Δ4-steroids with calcium cyanide in N-methylpyrrolidone gives 5α- and 5β-cyano-3-oxo-steroids. The isomer ratio is close to 1:1 for androstenone, cholestenone and testosterone, and about 3:5 (α:β 5-cyanide) for progesterone.
UR - http://www.scopus.com/inward/record.url?scp=37049124375&partnerID=8YFLogxK
U2 - 10.1039/J39670002465
DO - 10.1039/J39670002465
M3 - Article
SP - 2465
EP - 2466
JO - Journal of the Chemical Society C: Organic Chemistry
JF - Journal of the Chemical Society C: Organic Chemistry
SN - 0022-4952
ER -