Aspect-ratio-dependent interaction of molecular polymer brushes and multicellular tumour spheroids

Markus Müllner, Kylie Yang, Amandeep Kaur, Elizabeth J. New

Research output: Contribution to journalArticleResearchpeer-review

43 Citations (Scopus)

Abstract

Polymer nanoparticles based on molecular polymer brushes allow precise and independent tailoring of nanoparticle characteristics. This enables the synthesis of soft hydrophilic polymer particles with matching composition and surface chemistry where only the aspect-ratio is varied. PEGylated brush nanoparticles revealed that brush nanorods exhibit higher association and penetration into multicellular tumour spheroids compared to their spherical or filamentous counterparts.

Original languageEnglish
Pages (from-to)3461-3465
Number of pages5
JournalPolymer Chemistry
Volume9
Issue number25
DOIs
Publication statusPublished - 7 Jul 2018
Externally publishedYes

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