@article{da63341de3144a3fb8152e0a9d9b723a,
title = "Asia-Pacific guidelines for managing functional dyspepsia overlapping with other gastrointestinal symptoms",
abstract = "Contemporary systems for the diagnosis and management gastrointestinal symptoms not attributable to organic diseases (Functional GI Disorders, FGID, now renamed Disorders of Gut-Brain Interaction, DGBI) seek to categorize patients into narrowly defined symptom-based sub-classes to enable targeted treatment of patient cohorts with similar underlying putative pathophysiology. However, an overlap of symptom categories frequently occurs and has a negative impact on treatment outcomes. There is a lack of guidance on their management. An Asian Pacific Association of Gastroenterology (APAGE) working group was set up to develop clinical practice guidelines for management of patients with functional dyspepsia (FD) who have an overlap with another functional gastrointestinal disorder: FD with gastroesophageal reflux (FD-GERD), epigastric pain syndrome with irritable bowel syndrome (EPS-IBS), postprandial distress syndrome with IBS (PDS-IBS), and FD-Constipation. We identified putative pathophysiology to provide a basis for treatment recommendations. A management algorithm is presented to guide primary and secondary care clinicians.",
keywords = "dyspepsia, epidemiology, functional, gastrointestinal, management, overlap, pathophysiology",
author = "Gwee, {Kok Ann} and Lee, {Yeong Yeh} and Hidekazu Suzuki and Ghoshal, {Uday Chand} and Gerald Holtmann and Tao Bai and Giovanni Barbara and Chen, {Min hu} and Chua, {Andrew Seng Boon} and Gibson, {Peter R.} and Xiaohua Hou and Jinsong Liu and Atsushi Nakajima and Nitesh Pratap and Sanjeev Sachdeva and Siah, {Kewin Tien Ho} and Soh, {Alex Yu Sen} and Kentaro Sugano and Jan Tack and Tan, {Victoria Ping Yi} and Xudong Tang and Marjorie Walker and Wu, {Deng Chyang} and Xiao, {Ying Lian} and Zulkifli, {Khairil Khuzaini} and Clarissa Toh",
note = "Funding Information: KAG, Adare (advisory board) and Biocodex (advisory board). YYL, Danone‐Dumex (M) Sdn Bhd (advisory board). HS, received scholarship funds for research from Daiichi‐Sankyo, Otsuka Pharmaceutical Co, Ltd, MSD Co., Mylan EPD, Tanabe, and Takeda Pharmaceutical Co. and received service honoraria from Astellas Pharm, AstraZeneca K.K., EA Pharma Co, Ltd, Mylan EPD, Otsuka Pharm, and Takeda Pharm. PRG has served as a consultant or advisory board member for Anatara, Atmo Biosciences, Immunic Therapeutics, Novozymes, Novoviah and Comvita. He has received research grants for investigator‐driven studies from Atmo Biosciences. He holds shares in Atmo Biosciences. His department financially benefits from the sales of a digital application, booklets and online courses on the FODMAP diet. All other co‐authors, no conflict of interest to declare. Declaration of conflict of interest: Funding Information: The working team was supported by a grant from the Asian Pacific Association of Gastroenterology (APAGE). Financial support: Publisher Copyright: {\textcopyright} 2022 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd.",
year = "2023",
month = feb,
doi = "10.1111/jgh.16046",
language = "English",
volume = "38",
pages = "197--209",
journal = "Journal of Gastroenterology and Hepatology",
issn = "0815-9319",
publisher = "Wiley-Blackwell",
number = "2",
}