Asia-Pacific guidelines for managing functional dyspepsia overlapping with other gastrointestinal symptoms

Kok Ann Gwee, Yeong Yeh Lee, Hidekazu Suzuki, Uday Chand Ghoshal, Gerald Holtmann, Tao Bai, Giovanni Barbara, Min hu Chen, Andrew Seng Boon Chua, Peter R. Gibson, Xiaohua Hou, Jinsong Liu, Atsushi Nakajima, Nitesh Pratap, Sanjeev Sachdeva, Kewin Tien Ho Siah, Alex Yu Sen Soh, Kentaro Sugano, Jan Tack, Victoria Ping Yi TanXudong Tang, Marjorie Walker, Deng Chyang Wu, Ying Lian Xiao, Khairil Khuzaini Zulkifli, Clarissa Toh

Research output: Contribution to journalReview ArticleOtherpeer-review

5 Citations (Scopus)


Contemporary systems for the diagnosis and management gastrointestinal symptoms not attributable to organic diseases (Functional GI Disorders, FGID, now renamed Disorders of Gut-Brain Interaction, DGBI) seek to categorize patients into narrowly defined symptom-based sub-classes to enable targeted treatment of patient cohorts with similar underlying putative pathophysiology. However, an overlap of symptom categories frequently occurs and has a negative impact on treatment outcomes. There is a lack of guidance on their management. An Asian Pacific Association of Gastroenterology (APAGE) working group was set up to develop clinical practice guidelines for management of patients with functional dyspepsia (FD) who have an overlap with another functional gastrointestinal disorder: FD with gastroesophageal reflux (FD-GERD), epigastric pain syndrome with irritable bowel syndrome (EPS-IBS), postprandial distress syndrome with IBS (PDS-IBS), and FD-Constipation. We identified putative pathophysiology to provide a basis for treatment recommendations. A management algorithm is presented to guide primary and secondary care clinicians.

Original languageEnglish
Pages (from-to)197-209
Number of pages13
JournalJournal of Gastroenterology and Hepatology
Issue number2
Publication statusPublished - Feb 2023


  • dyspepsia
  • epidemiology
  • functional
  • gastrointestinal
  • management
  • overlap
  • pathophysiology

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