Arterial thrombosis-insidious, unpredictable and deadly

Shaun Jackson

Research output: Contribution to journalArticleResearchpeer-review

339 Citations (Scopus)

Abstract

The formation of blood clots-thrombosis-at sites of atherosclerotic plaque rupture is a major clinical problem despite ongoing improvements in antithrombotic therapy. Progress in identifying the pathogenic mechanisms regulating arterial thrombosis has led to the development of newer therapeutics, and there is general anticipation that these treatments will have greater efficacy and improved safety. However, major advances in this field require the identification of specific risk factors for arterial thrombosis in affected individuals and a rethink of the one size fits all approach to antithrombotic therapy. A? 2011 Nature America, Inc. All rights reserved. Language of original document
Original languageEnglish
Pages (from-to)1423 - 1436
Number of pages14
JournalNature Medicine
Volume17
Issue number11
DOIs
Publication statusPublished - 2011

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