Arterial stiffness is associated with intracranial large artery disease among ethnic Chinese and South Asian ischemic stroke patients

Deidre Anne De Silva, Fung-Peng Woon, Hui Yee Gan, Christopher P. Chen, Hui Meng Chang, Tian Hai Koh, Bronwyn A. Kingwell, James D. Cameron, Meng Cheong Wong

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Objective: Intracranial large artery disease (ICLAD) is a common stroke subtype that carries a poor prognosis. We studied the association of arterial stiffness, a recognized risk factor for atherosclerosis and ICLAD among ethnic Chinese and South Asian ischemic stroke patients. Methods: In this prospective study, we recruited consecutive ischemic stroke patients of Chinese and South Asian ethnicity. ICLAD was assessed by transcranial color-coded Doppler or magnetic resonance angiographic studies. Arterial stiffness was measured by carotid-femoral pulse wave velocity (cPWV). Results: Among the 268 patients studied, the prevalence of ICLAD was 54% and median cPWV was 11.4 m/s (interquartile range 9.0-13.6 m/s). Patients with ICLAD had higher cPWV compared with those without (median 11.7 vs. 11.0 m/s, P = 0.015). In multivariate analysis, patients with ICLAD were significantly more likely to have cPWV measurements in the highest quintile (>14.1 m/s) compared with patients without ICLAD independently of other covariates [odds ratio 2.21, P = 0.038]. Conclusion: This study revealed a novel association between arterial stiffness and ICLAD among ischemic stroke patients. The findings suggest that arterial stiffness may be involved in the pathophysiology of ICLAD. Future studies should investigate the effects of reducing arterial stiffness among stroke patients with ICLAD.

Original languageEnglish
Pages (from-to)1453-1458
Number of pages6
JournalJournal of Hypertension
Issue number7
Publication statusPublished - Jul 2009
Externally publishedYes


  • Arterial stiffness
  • Central pulse wave velocity
  • Intracranial large artery disease
  • Ischemic stroke

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