Arterial stiffness as a cause of cognitive decline and dementia: A systematic review and meta-analysis

Matthew P Pase, Annie Herbert, Natalie Grima, Andrew Pipingas, Michael Francis O'Rourke

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64 Citations (Scopus)


Background: Although arterial stiffness has recently been con?rmed as a predictor of cardiovascular disease, the association between arterial stiffness and cognitive decline is less clear. Aim: We performed a systematic review and meta-analysis to examine the evidence for large artery stiffness as a cause of cognitive decline and dementia. Method: Electronic databases were systematically searched until September 2011 for studies reporting on the longitudinal relationship between any validated measure of large artery stiffness and cognitive decline or dementia. Meta-analysis was performed on four studies investigating the association between aortic pulse wave velocity and a decline in Mini-Mental State Examination scores.
Original languageEnglish
Pages (from-to)808 - 815
Number of pages8
JournalInternal Medicine Journal
Issue number7
Publication statusPublished - 2012

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