Arterial pre-hypertension and hypertension in intracranial versus extracranial cerebrovascular stenosis

D. Wang, Y. Zhou, Y. Guo, C. Wang, A. Wang, Z. Jin, X. Gao, S. Wu, X. Zhao, J. B. Jonas

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Abstract

Background and purpose: Since it has remained unclear whether arterial pre-hypertension is a risk factor for cerebrovascular diseases, potential associations between arterial pre-hypertension and intracranial arterial stenosis (ICAS) and extracranial arterial stenosis (ECAS) were assessed. Methods: The population-based Asymptomatic Polyvascular Abnormalities in Community Study was a sub-study of employees and retirees of the coal mining industry in China. Our study examined asymptomatic polyvascular abnormalities in a general population and with an age of 40+ years without history of stroke, transient ischaemic attacks and coronary heart disease. ICAS was diagnosed by transcranial Doppler sonography and was defined by peak flow velocity criteria; ECAS was diagnosed by carotid duplex sonography and was defined by the diameter of the common carotid artery or internal carotid artery. Results: Out of 4422 study participants, 711 (16.1%) subjects showed an asymptomatic ICAS and 292 (6.6%) showed an asymptomatic ECAS. After adjusting for relevant risk factors, higher prevalence of ICAS was significantly associated with higher prevalence of pre-hypertension [odds ratio (OR) 1.55; 95% confidence interval (CI) 1.11, 2.16; P = 0.010] and hypertension (OR 1.80; 95% CI 1.53, 2.11; P < 0.001). Stratified by gender, the association was stronger for men than for women. Asymptomatic ECAS was not significantly associated with the prevalence of pre-hypertension (OR 0.78; 95% CI 0.55, 1.10) or of hypertension (OR 1.06; 95% CI 0.91, 1.24). Conclusions: The results suggest that arterial pre-hypertension in addition to hypertension is associated with a higher prevalence of asymptomatic ICAS, more in men.

Original languageEnglish
Pages (from-to)533-539
Number of pages7
JournalEuropean Journal of Neurology
Volume22
Issue number3
DOIs
Publication statusPublished - 1 Mar 2015
Externally publishedYes

Keywords

  • Blood pressure
  • Extracranial artery stenosis
  • Hypertension
  • Intracranial artery stenosis
  • Pre-hypertension

Cite this

Wang, D. ; Zhou, Y. ; Guo, Y. ; Wang, C. ; Wang, A. ; Jin, Z. ; Gao, X. ; Wu, S. ; Zhao, X. ; Jonas, J. B. / Arterial pre-hypertension and hypertension in intracranial versus extracranial cerebrovascular stenosis. In: European Journal of Neurology. 2015 ; Vol. 22, No. 3. pp. 533-539.
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abstract = "Background and purpose: Since it has remained unclear whether arterial pre-hypertension is a risk factor for cerebrovascular diseases, potential associations between arterial pre-hypertension and intracranial arterial stenosis (ICAS) and extracranial arterial stenosis (ECAS) were assessed. Methods: The population-based Asymptomatic Polyvascular Abnormalities in Community Study was a sub-study of employees and retirees of the coal mining industry in China. Our study examined asymptomatic polyvascular abnormalities in a general population and with an age of 40+ years without history of stroke, transient ischaemic attacks and coronary heart disease. ICAS was diagnosed by transcranial Doppler sonography and was defined by peak flow velocity criteria; ECAS was diagnosed by carotid duplex sonography and was defined by the diameter of the common carotid artery or internal carotid artery. Results: Out of 4422 study participants, 711 (16.1{\%}) subjects showed an asymptomatic ICAS and 292 (6.6{\%}) showed an asymptomatic ECAS. After adjusting for relevant risk factors, higher prevalence of ICAS was significantly associated with higher prevalence of pre-hypertension [odds ratio (OR) 1.55; 95{\%} confidence interval (CI) 1.11, 2.16; P = 0.010] and hypertension (OR 1.80; 95{\%} CI 1.53, 2.11; P < 0.001). Stratified by gender, the association was stronger for men than for women. Asymptomatic ECAS was not significantly associated with the prevalence of pre-hypertension (OR 0.78; 95{\%} CI 0.55, 1.10) or of hypertension (OR 1.06; 95{\%} CI 0.91, 1.24). Conclusions: The results suggest that arterial pre-hypertension in addition to hypertension is associated with a higher prevalence of asymptomatic ICAS, more in men.",
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Wang, D, Zhou, Y, Guo, Y, Wang, C, Wang, A, Jin, Z, Gao, X, Wu, S, Zhao, X & Jonas, JB 2015, 'Arterial pre-hypertension and hypertension in intracranial versus extracranial cerebrovascular stenosis', European Journal of Neurology, vol. 22, no. 3, pp. 533-539. https://doi.org/10.1111/ene.12611

Arterial pre-hypertension and hypertension in intracranial versus extracranial cerebrovascular stenosis. / Wang, D.; Zhou, Y.; Guo, Y.; Wang, C.; Wang, A.; Jin, Z.; Gao, X.; Wu, S.; Zhao, X.; Jonas, J. B.

In: European Journal of Neurology, Vol. 22, No. 3, 01.03.2015, p. 533-539.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Arterial pre-hypertension and hypertension in intracranial versus extracranial cerebrovascular stenosis

AU - Wang, D.

AU - Zhou, Y.

AU - Guo, Y.

AU - Wang, C.

AU - Wang, A.

AU - Jin, Z.

AU - Gao, X.

AU - Wu, S.

AU - Zhao, X.

AU - Jonas, J. B.

PY - 2015/3/1

Y1 - 2015/3/1

N2 - Background and purpose: Since it has remained unclear whether arterial pre-hypertension is a risk factor for cerebrovascular diseases, potential associations between arterial pre-hypertension and intracranial arterial stenosis (ICAS) and extracranial arterial stenosis (ECAS) were assessed. Methods: The population-based Asymptomatic Polyvascular Abnormalities in Community Study was a sub-study of employees and retirees of the coal mining industry in China. Our study examined asymptomatic polyvascular abnormalities in a general population and with an age of 40+ years without history of stroke, transient ischaemic attacks and coronary heart disease. ICAS was diagnosed by transcranial Doppler sonography and was defined by peak flow velocity criteria; ECAS was diagnosed by carotid duplex sonography and was defined by the diameter of the common carotid artery or internal carotid artery. Results: Out of 4422 study participants, 711 (16.1%) subjects showed an asymptomatic ICAS and 292 (6.6%) showed an asymptomatic ECAS. After adjusting for relevant risk factors, higher prevalence of ICAS was significantly associated with higher prevalence of pre-hypertension [odds ratio (OR) 1.55; 95% confidence interval (CI) 1.11, 2.16; P = 0.010] and hypertension (OR 1.80; 95% CI 1.53, 2.11; P < 0.001). Stratified by gender, the association was stronger for men than for women. Asymptomatic ECAS was not significantly associated with the prevalence of pre-hypertension (OR 0.78; 95% CI 0.55, 1.10) or of hypertension (OR 1.06; 95% CI 0.91, 1.24). Conclusions: The results suggest that arterial pre-hypertension in addition to hypertension is associated with a higher prevalence of asymptomatic ICAS, more in men.

AB - Background and purpose: Since it has remained unclear whether arterial pre-hypertension is a risk factor for cerebrovascular diseases, potential associations between arterial pre-hypertension and intracranial arterial stenosis (ICAS) and extracranial arterial stenosis (ECAS) were assessed. Methods: The population-based Asymptomatic Polyvascular Abnormalities in Community Study was a sub-study of employees and retirees of the coal mining industry in China. Our study examined asymptomatic polyvascular abnormalities in a general population and with an age of 40+ years without history of stroke, transient ischaemic attacks and coronary heart disease. ICAS was diagnosed by transcranial Doppler sonography and was defined by peak flow velocity criteria; ECAS was diagnosed by carotid duplex sonography and was defined by the diameter of the common carotid artery or internal carotid artery. Results: Out of 4422 study participants, 711 (16.1%) subjects showed an asymptomatic ICAS and 292 (6.6%) showed an asymptomatic ECAS. After adjusting for relevant risk factors, higher prevalence of ICAS was significantly associated with higher prevalence of pre-hypertension [odds ratio (OR) 1.55; 95% confidence interval (CI) 1.11, 2.16; P = 0.010] and hypertension (OR 1.80; 95% CI 1.53, 2.11; P < 0.001). Stratified by gender, the association was stronger for men than for women. Asymptomatic ECAS was not significantly associated with the prevalence of pre-hypertension (OR 0.78; 95% CI 0.55, 1.10) or of hypertension (OR 1.06; 95% CI 0.91, 1.24). Conclusions: The results suggest that arterial pre-hypertension in addition to hypertension is associated with a higher prevalence of asymptomatic ICAS, more in men.

KW - Blood pressure

KW - Extracranial artery stenosis

KW - Hypertension

KW - Intracranial artery stenosis

KW - Pre-hypertension

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U2 - 10.1111/ene.12611

DO - 10.1111/ene.12611

M3 - Article

VL - 22

SP - 533

EP - 539

JO - European Journal of Neurology

JF - European Journal of Neurology

SN - 1351-5101

IS - 3

ER -