TY - JOUR
T1 - Aromatase overexpression in dysfunctional adipose tissue links obesity to postmenopausal breast cancer
AU - Wang, Xuyi
AU - Simpson, Evan Rutherford
AU - Brown, Kristy A
PY - 2015
Y1 - 2015
N2 - The number of breast cancer cases has increased in the last a few decades and this is believed to be associated with the increased prevalence of obesity worldwide. The risk of breast cancer increases with age beyond menopause and the relationship between obesity and the risk of breast cancer in postmenopausal women is well established. The majority of postmenopausal breast cancers are estrogen receptor (ER) positive and estrogens produced in the adipose tissue promotes tumor formation. Obesity results in the secretion of inflammatory factors that stimulate the expression of the aromatase enzyme, which converts androgens into estrogens in the adipose tissue. Evidence demonstrating a link between obesity and breast cancer has led to the investigation of metabolic pathways as novel regulators of estrogen production, including pathways that can be targeted to inhibit aromatase specifically within the breast. This review aims to present some of the key findings in this regard.
AB - The number of breast cancer cases has increased in the last a few decades and this is believed to be associated with the increased prevalence of obesity worldwide. The risk of breast cancer increases with age beyond menopause and the relationship between obesity and the risk of breast cancer in postmenopausal women is well established. The majority of postmenopausal breast cancers are estrogen receptor (ER) positive and estrogens produced in the adipose tissue promotes tumor formation. Obesity results in the secretion of inflammatory factors that stimulate the expression of the aromatase enzyme, which converts androgens into estrogens in the adipose tissue. Evidence demonstrating a link between obesity and breast cancer has led to the investigation of metabolic pathways as novel regulators of estrogen production, including pathways that can be targeted to inhibit aromatase specifically within the breast. This review aims to present some of the key findings in this regard.
UR - http://www.sciencedirect.com/science/article/pii/S0960076015300182
U2 - 10.1016/j.jsbmb.2015.07.008
DO - 10.1016/j.jsbmb.2015.07.008
M3 - Article
SN - 0960-0760
VL - 153
SP - 35
EP - 44
JO - The Journal of Steroid Biochemistry and Molecular Biology
JF - The Journal of Steroid Biochemistry and Molecular Biology
ER -
