Aromatase and its inhibition in behaviour, obsessive compulsive disorder and parkinsonism

Wah Chin Boon, Malcolm Horne

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Abstract

Oestrogens regulate normal behaviour and have been implicated in modulating pathological behaviour such as obsessive compulsive disorder and neurological disorder such as Parkinsonism. Therefore, by regulating the expression of the oestrogen-synthesising enzyme, aromatase, we may identify what behaviour is regulated by oestrogen. Inhibition of aromatase either genetically or pharmacologically has been reported to induce sexual behaviour impairment, compulsive behaviour and susceptibility to neurodegeneration.
Original languageEnglish
Pages (from-to)816 - 819
Number of pages4
JournalSteroids
Volume76
Issue number8
DOIs
Publication statusPublished - 2011

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