Arginine methylation of the B cell antigen receptor promotes differentiation

Simona Infantino, Beate Benz, Tanja Waldmann, Manfred Jung, Robert Schneider, Michael Reth

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57 Citations (Scopus)


Signals processed through the B cell antigen receptor (BCR) control both the proliferation and differentiation of B lymphocytes. How these different signaling modes are established at the BCR is poorly understood. We show that a conserved arginine in the tail sequence of the Igα subunit of the BCR is methylated by the protein arginine methyltransferase 1. This modification negatively regulates the calcium and PI-3 kinase pathways of the BCR while promoting signals leading to B cell differentiation. Thus, Igα arginine methylation can play an important role in specifying the outcome of BCR signaling.

Original languageEnglish
Pages (from-to)711-719
Number of pages9
JournalJournal of Experimental Medicine
Issue number4
Publication statusPublished - 12 Apr 2010
Externally publishedYes

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