Arginine methylation catalyzed by PRMT1 is required for B cell activation and differentiation

Simona Infantino, Amanda Light, Kristy O'donnell, Vanessa Bryant, Danielle T. Avery, Michael Elliott, Stuart G. Tangye, Gabrielle Belz, Fabienne Mackay, Stephane Richard, David Tarlinton

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Abstract

PRMT1 is an arginine methyltransferase involved in a variety of cell functions. Here the authors delete PRMT1 specifically in mature B cells to show the importance of arginine methylation for B cell proliferation, differentiation and survival, and thereby for humoral immunity.

Original languageEnglish
Article number891
Number of pages12
JournalNature Communications
Volume8
Issue number1
DOIs
Publication statusPublished - 1 Dec 2017

Cite this

Infantino, Simona ; Light, Amanda ; O'donnell, Kristy ; Bryant, Vanessa ; Avery, Danielle T. ; Elliott, Michael ; Tangye, Stuart G. ; Belz, Gabrielle ; Mackay, Fabienne ; Richard, Stephane ; Tarlinton, David. / Arginine methylation catalyzed by PRMT1 is required for B cell activation and differentiation. In: Nature Communications. 2017 ; Vol. 8, No. 1.
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Infantino, S, Light, A, O'donnell, K, Bryant, V, Avery, DT, Elliott, M, Tangye, SG, Belz, G, Mackay, F, Richard, S & Tarlinton, D 2017, 'Arginine methylation catalyzed by PRMT1 is required for B cell activation and differentiation', Nature Communications, vol. 8, no. 1, 891. https://doi.org/10.1038/s41467-017-01009-1

Arginine methylation catalyzed by PRMT1 is required for B cell activation and differentiation. / Infantino, Simona; Light, Amanda; O'donnell, Kristy; Bryant, Vanessa; Avery, Danielle T.; Elliott, Michael; Tangye, Stuart G.; Belz, Gabrielle; Mackay, Fabienne; Richard, Stephane; Tarlinton, David.

In: Nature Communications, Vol. 8, No. 1, 891, 01.12.2017.

Research output: Contribution to journalArticleResearchpeer-review

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