Arginine methylation catalyzed by PRMT1 is required for B cell activation and differentiation

Simona Infantino, Amanda Light, Kristy O'donnell, Vanessa Bryant, Danielle T. Avery, Michael Elliott, Stuart G. Tangye, Gabrielle Belz, Fabienne Mackay, Stephane Richard, David Tarlinton

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9 Citations (Scopus)

Abstract

PRMT1 is an arginine methyltransferase involved in a variety of cell functions. Here the authors delete PRMT1 specifically in mature B cells to show the importance of arginine methylation for B cell proliferation, differentiation and survival, and thereby for humoral immunity.

Original languageEnglish
Article number891
Number of pages12
JournalNature Communications
Volume8
Issue number1
DOIs
Publication statusPublished - 1 Dec 2017

Cite this

Infantino, S., Light, A., O'donnell, K., Bryant, V., Avery, D. T., Elliott, M., Tangye, S. G., Belz, G., Mackay, F., Richard, S., & Tarlinton, D. (2017). Arginine methylation catalyzed by PRMT1 is required for B cell activation and differentiation. Nature Communications, 8(1), [891]. https://doi.org/10.1038/s41467-017-01009-1