Are branched chain fatty acids the natural substrates for P450 BM3?

Max J. Cryle; Rocio D. Espinoza; Sarah J. Smith; Nicholas J. Matovic; James J. De Voss

doi:10.1039/b601202g

Are branched chain fatty acids the natural substrates for P450 BM3?

Max J. Cryle
, Rocio D. Espinoza
, Sarah J. Smith
, Nicholas J. Matovic
, James J. De Voss

Research output: Contribution to journal › Article › Research › peer-review

43 Citations (Scopus)

Abstract

Branched chain fatty acids are substrates for cytochrome P450_BM3 (CYP102) from Bacillus megaterium; oxidation of C₁₅ and C ₁₇ iso and anteiso fatty acids by P450_BM3 leads to the formation of hydroxylated products that possess high levels of regiochemical and stereochemical purity.

Original language	English
Pages (from-to)	2353-2355
Number of pages	3
Journal	Chemical Communications
Issue number	22
DOIs	https://doi.org/10.1039/b601202g
Publication status	Published - 2006
Externally published	Yes

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10.1039/b601202g

Cite this

@article{a5819ff60645474ea92e226eca9733a8,

title = "Are branched chain fatty acids the natural substrates for P450 BM3?",

abstract = "Branched chain fatty acids are substrates for cytochrome P450BM3 (CYP102) from Bacillus megaterium; oxidation of C15 and C 17 iso and anteiso fatty acids by P450BM3 leads to the formation of hydroxylated products that possess high levels of regiochemical and stereochemical purity.",

author = "Cryle, \{Max J.\} and Espinoza, \{Rocio D.\} and Smith, \{Sarah J.\} and Matovic, \{Nicholas J.\} and \{De Voss\}, \{James J.\}",

year = "2006",

doi = "10.1039/b601202g",

language = "English",

pages = "2353--2355",

journal = "Chemical Communications",

issn = "1359-7345",